Barrett's oesophagus

Ralf Kiesslich, Kerry Dunbar, Markus F. Neurath

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Barrett's oesophagus is known to be a premalignant condition in patients with gastroesophageal reflux disease, and most adenocarcinomas of the distal oesophagus have been shown to arise in Barrett's tissue. Barrett's oesophagus is defined histologically by the presence of specialised columnar epithelium (SCE) with goblet cells. The columnar-lined lower oesophagus can be identified during standard upper endoscopy. SCE is often present in a patchy mosaic contribution within columnar-lined lower oesophagus and can be overlooked by random biopsies, resulting in biopsies of the cardia or gastric type of mucosa without goblet cells. However, it has been suggested that four-quadrant step biopsies within the columnar-lined lower oesophagus should serve as the gold standard for diagnosing Barrett's epithelium and Barrett's-associated neoplastic changes.

Original languageEnglish (US)
Title of host publicationAtlas of Endomicroscopy
PublisherSpringer Berlin Heidelberg
Pages57-59
Number of pages3
ISBN (Print)9783540347576
DOIs
StatePublished - 2008

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Barrett Esophagus
Esophagus
Goblet Cells
Biopsy
Epithelium
Cardia
Gastroesophageal Reflux
Gastric Mucosa
Endoscopy

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Kiesslich, R., Dunbar, K., & Neurath, M. F. (2008). Barrett's oesophagus. In Atlas of Endomicroscopy (pp. 57-59). Springer Berlin Heidelberg. https://doi.org/10.1007/978-3-540-35115-3_8

Barrett's oesophagus. / Kiesslich, Ralf; Dunbar, Kerry; Neurath, Markus F.

Atlas of Endomicroscopy. Springer Berlin Heidelberg, 2008. p. 57-59.

Research output: Chapter in Book/Report/Conference proceedingChapter

Kiesslich, R, Dunbar, K & Neurath, MF 2008, Barrett's oesophagus. in Atlas of Endomicroscopy. Springer Berlin Heidelberg, pp. 57-59. https://doi.org/10.1007/978-3-540-35115-3_8
Kiesslich R, Dunbar K, Neurath MF. Barrett's oesophagus. In Atlas of Endomicroscopy. Springer Berlin Heidelberg. 2008. p. 57-59 https://doi.org/10.1007/978-3-540-35115-3_8
Kiesslich, Ralf ; Dunbar, Kerry ; Neurath, Markus F. / Barrett's oesophagus. Atlas of Endomicroscopy. Springer Berlin Heidelberg, 2008. pp. 57-59
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