Barrett's esophagus: Genetic and cell changes

Rhonda F. Souza, Giancarlo Freschi, Antonio Taddei, Maria Novella Ringressi, Paolo Bechi, Francesca Castiglione, Duccio Rossi Degl'Innocenti, George Triadafilopoulos, Jean S. Wang, Andrew C. Chang, Hugh Barr, Manisha Bajpai, Kiron M. Das, Paul M. Schneider, Kausilia K. Krishnadath, Usha Malhotra, John P. Lynch

Research output: Contribution to journalArticle

Abstract

The following includes commentaries on how genetic code of Barrett's esophagus (BE) patients, the mechanisms for GERD-induced esophageal expression of caudal homeobox, and the development of Barrett's metaplasia are increasingly better known, including the role of stromal genes in oncogenesis. Additional lessons have been learned fromin vitromodels in nonneoplastic cell lines, yet there are limitations to what can be expected from BE-derived cell lines. Other topics discussed include clonal diversity in Barrett's esophagus; the application of peptide arrays to clinical samples of metaplastic mucosa; proliferation and apoptosis of Barrett's cell lines; tissue biomarkers for neoplasia; and transcription factors associated with BE.

Original languageEnglish (US)
Pages (from-to)18-35
Number of pages18
JournalAnnals of the New York Academy of Sciences
Volume1232
Issue number1
DOIs
StatePublished - Sep 2011
Externally publishedYes

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Keywords

  • Adenocarcinoma
  • BAR-T cells
  • Barrett's esophagus
  • Bile
  • BMP-4
  • CDKN2A
  • CDX-1gene
  • CDX-2 gene
  • Hedgehog pathway
  • Hox genes
  • IGF-1R genotype
  • Intestinal metaplasia
  • MAb Das-1
  • Mitogen-activated protein kinase
  • NF-κB
  • P16
  • P53
  • TP53
  • Villin

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

Cite this

Souza, R. F., Freschi, G., Taddei, A., Ringressi, M. N., Bechi, P., Castiglione, F., Degl'Innocenti, D. R., Triadafilopoulos, G., Wang, J. S., Chang, A. C., Barr, H., Bajpai, M., Das, K. M., Schneider, P. M., Krishnadath, K. K., Malhotra, U., & Lynch, J. P. (2011). Barrett's esophagus: Genetic and cell changes. Annals of the New York Academy of Sciences, 1232(1), 18-35. https://doi.org/10.1111/j.1749-6632.2011.06043.x