Barrett oesophagus and adenocarcinoma: An overview of epidemiologic, conceptual and clinical issues

J. W. Van Sandick, J. J B Van Lanschot, G. N J Tytgat, G. J A Offerhaus, H. Obertop

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


A steady increase in the incidence of adenocarcinoma of the oesophagus and oesophagogastric junction has been observed in Western countries. Patients with distinctive-type Barrett oesophagus are predisposed to developing adenocarcinoma of the oesophagus. Distinctive-type Barrett oesophagus is defined by the presence of intestinal-like goblet cells anywhere in the oesophagus. Adenocarcinomas of the oesophagogastric junction may be associated with short segments of intestinal-type columnar epithelium in the distal oesophagus. Prognosis after surgical resection for cancer of the oesophagus or oesophagogastric junction is strongly affected by the extent of the disease at the time of diagnosis. The identification of Barrett oesophagus as a premalignant condition, the recognition of a stepwise neoplastic progression, along with the poor survival rates of advanced oesophageal adenocarcinoma have initiated the practice of endoscopic biopsy surveillance for patients with Barrett oesophagus. There is supporting evidence that endoscopic biopsy surveillance of Barrett oesophagus permits detection of malignancy at an early stage with favourable results after oesophageal resection. Endoscopic treatment modalities should at this time not be generally adopted in the management of patients with early invasive adenocarcinoma of the oesophagus or oesophagogastric junction.

Original languageEnglish (US)
Pages (from-to)51-60
Number of pages10
JournalScandinavian Journal of Gastroenterology, Supplement
Issue number234
StatePublished - 2001
Externally publishedYes


  • Adenocarcinoma
  • Barrett oesophagus
  • Dysplasia
  • Early cancer
  • Endoscopy
  • Histology
  • Intestinal metaplasia
  • Oesophageal resection
  • Oesophagogastric junction
  • Review

ASJC Scopus subject areas

  • Gastroenterology


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