Baroreceptor output during normal and obstructed breathing and Mueller maneuvers.

Robert S Fitzgerald, J. L. Robotham, A. Anand

Research output: Contribution to journalArticle

Abstract

Cardiovascular control during asthma and other forms of obstructed breathing has not been extensively investigated. Previous studies in dogs have shown that obstructed breathing or an inspiratory effort against a blocked airway (Mueller maneuver) provoke large oscillations in blood pressure. During the inspiratory phase transmural systolic pressure relative to atmosphere drops initially, but transmural systolic pressure relative to intrathoracic pressure can remain unchanged or even increase. Because the carotid baroreceptors are located in the extrathoracic circulation, whereas the aortic baroreceptors are located in the intrathoracic circulation, and each responds to local transmural arterial pressure, simultaneous baroreceptor output from these two areas was measured in the anesthetized cat during normal and obstructed breathing and during Mueller maneuvers. Both whole-nerve and single-fiber preparations showed a significantly decreased output from the carotid baroreceptors during obstructed inspiratory efforts, whereas aortic baroreceptor output decreased significantly less or not at all. Transmural systolic pressure decreased significantly less in the aorta than in the carotid regions. Further, the aortic baroreceptors were more sensitive to changes in pulse pressure than were the carotid baroreceptors. These results suggest a mechanism for stabilizing the cardiac responses to precipitous falls in blood pressure that occur in obstructed breathing.

Original languageEnglish (US)
JournalThe American journal of physiology
Volume240
Issue number5
StatePublished - May 1981

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Pressoreceptors
Respiration
Blood Pressure
Atmosphere
Nerve Fibers
Aorta
Arterial Pressure
Cats
Asthma
Dogs
Pressure

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Baroreceptor output during normal and obstructed breathing and Mueller maneuvers. / Fitzgerald, Robert S; Robotham, J. L.; Anand, A.

In: The American journal of physiology, Vol. 240, No. 5, 05.1981.

Research output: Contribution to journalArticle

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