TY - JOUR
T1 - Bariatric Radioembolization
T2 - A Pilot Study on Technical Feasibility and Safety in a Porcine Model
AU - Pasciak, Alexander S.
AU - Bourgeois, Austin C.
AU - Paxton, Ben E.
AU - Nodit, Laurentia
AU - Coan, Patricia N.
AU - Kraitchman, Dara
AU - Stinnett, Sandra S.
AU - Patel, Vijay M.
AU - Fu, Yingli
AU - Adams, Joleen K.
AU - Tolbert, M. Katherine
AU - Lux, Cassie N.
AU - Arepally, Aravind
AU - Bradley, Yong C.
N1 - Publisher Copyright:
© 2016 SIR
PY - 2016/10/1
Y1 - 2016/10/1
N2 - Purpose To evaluate feasibility of left gastric artery (LGA) yttrium-90 (90Y) radioembolization as potential treatment for obesity in a porcine model. Materials and Methods This study included 8 young female pigs (12–13 weeks, 21.8–28.1 kg). Six animals received infusions of 90Y resin microspheres (46.3–105.1 MBq) into the main LGA and the gastric artery arising from the splenic artery. Animal weight and serum ghrelin were measured before treatment and weekly thereafter. Animals were euthanized 69–74 days after treatment, and histologic analyses of mucosal integrity and ghrelin immunoreactive cell density were performed. Results Superficial mucosal ulcerations < 3.0 cm2 were noted in 5 of 6 treated animals. Ghrelin immunoreactive cell density was significantly lower in treated versus untreated animals in the stomach fundus (13.5 vs 34.8, P < .05) and stomach body (11.2 vs 19.8, P < .05). Treated animals gained less weight than untreated animals over the study duration (40.2 kg ± 5.4 vs 54.7 kg ± 6.5, P = .053). Average fundic parietal area (165 cm2 vs 282 cm2, P = .067) and average stomach weight (297.2 g vs 397.0 g, P = .067) were decreased in treated versus untreated animals. Trichrome staining revealed significantly more fibrosis in treatment animals compared with control animals (13.0 vs 8.6, P < .05). No significant differences were identified in plasma ghrelin concentrations (P = .24). Conclusions LGA 90Y radioembolization is promising as a potential treatment for obesity. A larger preclinical study is needed to evaluate the safety and efficacy of this procedure further.
AB - Purpose To evaluate feasibility of left gastric artery (LGA) yttrium-90 (90Y) radioembolization as potential treatment for obesity in a porcine model. Materials and Methods This study included 8 young female pigs (12–13 weeks, 21.8–28.1 kg). Six animals received infusions of 90Y resin microspheres (46.3–105.1 MBq) into the main LGA and the gastric artery arising from the splenic artery. Animal weight and serum ghrelin were measured before treatment and weekly thereafter. Animals were euthanized 69–74 days after treatment, and histologic analyses of mucosal integrity and ghrelin immunoreactive cell density were performed. Results Superficial mucosal ulcerations < 3.0 cm2 were noted in 5 of 6 treated animals. Ghrelin immunoreactive cell density was significantly lower in treated versus untreated animals in the stomach fundus (13.5 vs 34.8, P < .05) and stomach body (11.2 vs 19.8, P < .05). Treated animals gained less weight than untreated animals over the study duration (40.2 kg ± 5.4 vs 54.7 kg ± 6.5, P = .053). Average fundic parietal area (165 cm2 vs 282 cm2, P = .067) and average stomach weight (297.2 g vs 397.0 g, P = .067) were decreased in treated versus untreated animals. Trichrome staining revealed significantly more fibrosis in treatment animals compared with control animals (13.0 vs 8.6, P < .05). No significant differences were identified in plasma ghrelin concentrations (P = .24). Conclusions LGA 90Y radioembolization is promising as a potential treatment for obesity. A larger preclinical study is needed to evaluate the safety and efficacy of this procedure further.
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U2 - 10.1016/j.jvir.2016.05.020
DO - 10.1016/j.jvir.2016.05.020
M3 - Article
C2 - 27492867
AN - SCOPUS:84995605624
SN - 1051-0443
VL - 27
SP - 1509
EP - 1517
JO - Journal of Vascular and Interventional Radiology
JF - Journal of Vascular and Interventional Radiology
IS - 10
ER -