TY - JOUR
T1 - Bare fiber photodynamic therapy using porfimer sodium for esophageal disease
AU - Wolfsen, Herbert
AU - Canto, Marcia
AU - Etemad, Bob
AU - Greenwald, Bruce
AU - Gress, Frank
AU - Schembre, Drew
AU - Muthusamy, V. Raman
AU - Ribeiro, Afonso
AU - Sharma, Virender
AU - Ginsberg, Gregory
PY - 2006/6
Y1 - 2006/6
N2 - During Digestive Disease Week 2005 in Chicago, Illinois, our group of 10 gastrointestinal photodynamic therapists met to discuss variations in procedural technique and treatment protocols. An extensive review of the use of photodynamic therapy (PDT) for esophageal disease has recently been published elsewhere [Wolfsen HC. Present status of photodynamic therapy for high-grade dysplasia in Barrett's esophagus. J Clin Gastroenterol 2005;39(3):189-202]. This report, based mostly on clinical experience and common sense rather than evidence-based medicine, is a detailed discussion of pragmatic issues. In summary, our centers treat patients with Barrett's dysplasia, Barrett's or squamous cell carcinoma using the photosensitizer porfimer sodium (2 mg/kg total body weight) and bare fiber PDT (no fiber centering devices). Aggressive suppression of gastric acid is uniformly emphasized. The most common technique variables were the light energy source, light dosimetry and the amount of Barrett's mucosa treated during a course of PDT. Standardization of porfimer sodium PDT procedures and light dosimetry may enhance treatment outcomes.
AB - During Digestive Disease Week 2005 in Chicago, Illinois, our group of 10 gastrointestinal photodynamic therapists met to discuss variations in procedural technique and treatment protocols. An extensive review of the use of photodynamic therapy (PDT) for esophageal disease has recently been published elsewhere [Wolfsen HC. Present status of photodynamic therapy for high-grade dysplasia in Barrett's esophagus. J Clin Gastroenterol 2005;39(3):189-202]. This report, based mostly on clinical experience and common sense rather than evidence-based medicine, is a detailed discussion of pragmatic issues. In summary, our centers treat patients with Barrett's dysplasia, Barrett's or squamous cell carcinoma using the photosensitizer porfimer sodium (2 mg/kg total body weight) and bare fiber PDT (no fiber centering devices). Aggressive suppression of gastric acid is uniformly emphasized. The most common technique variables were the light energy source, light dosimetry and the amount of Barrett's mucosa treated during a course of PDT. Standardization of porfimer sodium PDT procedures and light dosimetry may enhance treatment outcomes.
KW - Endobronchial ultrasound
KW - Endoscopic ultrasound
KW - Lung cancer
KW - Phototoxicity
KW - Stricture
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U2 - 10.1016/j.pdpdt.2006.03.004
DO - 10.1016/j.pdpdt.2006.03.004
M3 - Article
C2 - 25049096
AN - SCOPUS:33646901054
SN - 1572-1000
VL - 3
SP - 87
EP - 92
JO - Photodiagnosis and photodynamic therapy
JF - Photodiagnosis and photodynamic therapy
IS - 2
ER -