Barbiturate anesthetics inhibit thromboxane-, potassium-, but not angiotensin-induced pulmonary vasoconstriction

A. J. McShane, K. Crowley, J. R. Shayevitz, J. R. Michael, N Franklin Adkinson, R. J. Traystman, G. H. Gurtner

Research output: Contribution to journalArticle

Abstract

Administration of the oxidant lipid peroxide tertiary butyl hydroperoxide (t-bu-OOH) in the isolated rabbit lung leads to acute pulmonary vasoconstriction, which is caused by the synthesis of thromboxane. The inhalation anesthetics, halothane, nitrous oxide, and cyclopropane, markedly enhance t-bu-OOH-induced pulmonary vasoconstriction and thromboxane production. The effects of the intravenous (iv) barbiturates thiopental and pentobarbital on t-bu-OOH-induced vasoconstriction were studied. Thiopental completely and pentobarbital partially blocked t-bu-OOH-induced vasoconstriction. Thiopental inhibited t-bu-OOH-induced synthesis of thromboxane and prostacyclin but pentobarbital did not. This inhibitory action of thiopental may be due to its antioxidant properties because similar inhibition has been observed of t-bu-OOH-induced thromboxane production with the antioxidants, vitamin E, or butylated hydroxylanisole. Thiopental and pentobarbital also inhibited the vasoconstriction induced by a thromboxane analog, epoxymethano prostaglandin H2 (U46619). Finally, both barbiturates partially inhibited the pulmonary vasoconstriction caused by potassium chloride, which requires calcium entry, but they did not inhibit the constriction caused by angiotensin II, which does not require calcium entry. These results suggest that pentobarbital and thiopental may block pulmonary vasoconstriction by inhibiting calcium entry.

Original languageEnglish (US)
Pages (from-to)775-779
Number of pages5
JournalAnesthesiology
Volume70
Issue number5
StatePublished - 1989

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Thromboxanes
Angiotensins
Vasoconstriction
Thiopental
Anesthetics
Potassium
Pentobarbital
Lung
Barbiturates
Calcium
Antioxidants
Prostaglandin H2
Inhalation Anesthetics
tert-Butylhydroperoxide
15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid
Potassium Chloride
Lipid Peroxides
Nitrous Oxide
Halothane
Epoprostenol

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

Cite this

McShane, A. J., Crowley, K., Shayevitz, J. R., Michael, J. R., Adkinson, N. F., Traystman, R. J., & Gurtner, G. H. (1989). Barbiturate anesthetics inhibit thromboxane-, potassium-, but not angiotensin-induced pulmonary vasoconstriction. Anesthesiology, 70(5), 775-779.

Barbiturate anesthetics inhibit thromboxane-, potassium-, but not angiotensin-induced pulmonary vasoconstriction. / McShane, A. J.; Crowley, K.; Shayevitz, J. R.; Michael, J. R.; Adkinson, N Franklin; Traystman, R. J.; Gurtner, G. H.

In: Anesthesiology, Vol. 70, No. 5, 1989, p. 775-779.

Research output: Contribution to journalArticle

McShane, AJ, Crowley, K, Shayevitz, JR, Michael, JR, Adkinson, NF, Traystman, RJ & Gurtner, GH 1989, 'Barbiturate anesthetics inhibit thromboxane-, potassium-, but not angiotensin-induced pulmonary vasoconstriction', Anesthesiology, vol. 70, no. 5, pp. 775-779.
McShane, A. J. ; Crowley, K. ; Shayevitz, J. R. ; Michael, J. R. ; Adkinson, N Franklin ; Traystman, R. J. ; Gurtner, G. H. / Barbiturate anesthetics inhibit thromboxane-, potassium-, but not angiotensin-induced pulmonary vasoconstriction. In: Anesthesiology. 1989 ; Vol. 70, No. 5. pp. 775-779.
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