TY - JOUR
T1 - Banff Histopathological Consensus Criteria for Preimplantation Kidney Biopsies
AU - the Banff Working Group
AU - Liapis, H.
AU - Gaut, J. P.
AU - Klein, C.
AU - Bagnasco, S.
AU - Kraus, E.
AU - Farris, A. B.
AU - Honsova, E.
AU - Perkowska-Ptasinska, A.
AU - David, D.
AU - Goldberg, J.
AU - Smith, M.
AU - Mengel, M.
AU - Haas, M.
AU - Seshan, S.
AU - Pegas, K. L.
AU - Horwedel, T.
AU - Paliwa, Y.
AU - Gao, X.
AU - Landsittel, D.
AU - Randhawa, P.
N1 - Funding Information:
We acknowledge support from Roche Organ Transplantation Research Foundation Grant 608390948 (to the Banff Foundation for Allograft Pathology for infrastructure support). H.L., J.P.G., P.R. contributed equally in the design, data collection, and data analysis and manuscript preparation. C.K. provided clinical information of the biopsies used for digital evaluation. S.B., E.K., B.F., S.S., M.M., M.H. participated in digital scoring, contributed clinical follow up/graft survival data and or critically reviewed the manuscript. E.H., A.P.P., D.D., H.G., M.S., K.L.P. contributed detailed histopathologic and clinical data of pre and post implantation biopsies and graft/patient survival data. V.P., D.L., T.H., X.G. performed statistics. The following participated in digital scoring and or contributed ideas and suggestions. Afrousian Marjan University of Texas Medical Branch, Galveston, TX Alexander Mariam Mayo Clinic, Rochester, MN Arend Lois Johns Hopkins University Hospital, Baltimore, MD Bajema Ingeborg Leiden University Medical Center, Leiden, the Netherlands Balasubramanian Manjula Albert Einstein Medical Center, Philadelphia, PA Chander Praveen New York Medical College Cheunsuchon Boonyarit Siriaj Hospital, Mahidol University, Bangkok, Thailand Cornell Lynn Mayo Clinic, Rochester, MN de Franco Marcello University of San Paulo, Renal Transplant Service, Brazil Farkash Evan University of Michigan Med School, Ann Arbor, MI Fogo Agnes Vanderbilt University Fyfe Billie Robert Wood Johnson Med. School, New Brunswick, NJ Iskander Samy Wake Forest University School of Medicine, NC Kemeny Eva University Szeged, Szeged, Hungary Lukic Dusan McMaster University, Hamilton, Ontario, Canada Mazzucco Gianna Universita Degli Studi Di Torino, Italy Monga Guido Università del Piemonte Orientale “A. Avogadro,” Novara, Italy Mubarak Muhammed University Hospital Basel, Basel, Switzerland Nickeleit Volker University of North Carolina, Chapel Hill, NC Nizze Horst Universitat Rostock, Germany Papadimitriou John University of Maryland, Baltimore, Maryland Picken Maria Loyola University Medical Center, Maywood, IL Pullman James Montefiore Medical Center, Bronx, NY Racusen Lorraine Johns Hopkins University Hospital, Baltimore, MD Sadeghipour Alireza Atieh hospital, Tehran Tehran, Iran Saker Zakaria National Center of Urology, Georgia (Tbilisi, Georgia) Setty Suman University of Illinois College of Medicine, Chicago, IL Sharma Shree Nephropath, Little Rock, AR Sheaff Michael Barts Health NHS Trust, London, UK Soares Maria F. Universidade Federal do Parana, Curitiba, Brazil Solez Kim University of Alberta, Edmonton Alberta, Canada Taheri Diana Isfahan University of Medical Sciences, Isfahan Isfahan, Iran Tan Jane Stanford Health Care, Stanford, CA Troxell Megan Oregon Health Science University, Portland, OR Truong Luan Weill Medical College of Cornell University, Houston, TX Vasquez Martul Eduardo Hospital Universitario A Coruna, A Coruna, Spain Walker Patrick Nephropath, Little Rock, AR Wellen Jason Dept. of Surgery, Washington University, St. Louis, MO
Publisher Copyright:
© Copyright 2016 The American Society of Transplantation and the American Society of Transplant Surgeons
PY - 2017/1/1
Y1 - 2017/1/1
N2 - The Banff working group on preimplantation biopsy was established to develop consensus criteria (best practice guidelines) for the interpretation of preimplantation kidney biopsies. Digitally scanned slides were used (i) to evaluate interobserver variability of histopathologic findings, comparing frozen sections with formalin-fixed, paraffin-embedded tissue of wedge and needle core biopsies, and (ii) to correlate consensus histopathologic findings with graft outcome in a cohort of biopsies from international medical centers. Intraclass correlations (ICCs) and univariable and multivariable statistical analyses were performed. Good to fair reproducibility was observed in semiquantitative scores for percentage of glomerulosclerosis, arterial intimal fibrosis and interstitial fibrosis on frozen wedge biopsies. Evaluation of frozen wedge and core biopsies was comparable for number of glomeruli, but needle biopsies showed worse ICCs for glomerulosclerosis, interstitial fibrosis and tubular atrophy. A consensus evaluation form is provided to help standardize the reporting of histopathologic lesions in donor biopsies. It should be recognized that histologic parameters may not correlate with graft outcome in studies based on organs deemed to be acceptable after careful clinical assessment. Significant limitations remain in the assessment of implantation biopsies.
AB - The Banff working group on preimplantation biopsy was established to develop consensus criteria (best practice guidelines) for the interpretation of preimplantation kidney biopsies. Digitally scanned slides were used (i) to evaluate interobserver variability of histopathologic findings, comparing frozen sections with formalin-fixed, paraffin-embedded tissue of wedge and needle core biopsies, and (ii) to correlate consensus histopathologic findings with graft outcome in a cohort of biopsies from international medical centers. Intraclass correlations (ICCs) and univariable and multivariable statistical analyses were performed. Good to fair reproducibility was observed in semiquantitative scores for percentage of glomerulosclerosis, arterial intimal fibrosis and interstitial fibrosis on frozen wedge biopsies. Evaluation of frozen wedge and core biopsies was comparable for number of glomeruli, but needle biopsies showed worse ICCs for glomerulosclerosis, interstitial fibrosis and tubular atrophy. A consensus evaluation form is provided to help standardize the reporting of histopathologic lesions in donor biopsies. It should be recognized that histologic parameters may not correlate with graft outcome in studies based on organs deemed to be acceptable after careful clinical assessment. Significant limitations remain in the assessment of implantation biopsies.
KW - biopsy
KW - clinical research/practice
KW - donors and donation: deceased
KW - kidney (allograft) function/dysfunction
KW - kidney failure/injury
KW - pathology/histopathology
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U2 - 10.1111/ajt.13929
DO - 10.1111/ajt.13929
M3 - Article
C2 - 27333454
AN - SCOPUS:84995685158
SN - 1600-6135
VL - 17
SP - 140
EP - 150
JO - American Journal of Transplantation
JF - American Journal of Transplantation
IS - 1
ER -