Banff 2011 meeting report: New concepts in antibody-mediated rejection

M. Mengel, B. Sis, M. Haas, R. B. Colvin, P. F. Halloran, L. C. Racusen, K. Solez, L. Cendales, A. J. Demetris, C. B. Drachenberg, C. F. Farver, E. R. Rodriguez, W. D. Wallace, D. Glotz

Research output: Contribution to journalArticle

Abstract

The 11th Banff meeting was held in Paris, France, from June 5 to 10, 2011, with a focus on refining diagnostic criteria for antibody-mediated rejection (ABMR). The major outcome was the acknowledgment of C4d-negative ABMR in kidney transplants. Diagnostic criteria for ABMR have also been revisited in other types of transplants. It was recognized that ABMR is associated with heterogeneous phenotypes even within the same type of transplant. This highlights the necessity of further refining the respective diagnostic criteria, and is of particular significance for the design of randomized clinical trials. A reliable phenotyping will allow for definition of robust end-points. To address this unmet need and to allow for an evidence-based refinement of the Banff classification, Banff Working Groups presented multicenter data regarding the reproducibility of features relevant to the diagnosis of ABMR. However, the consensus was that more data are necessary and further Banff Working Group activities were initiated. A new Banff working group was created to define diagnostic criteria for ABMR in kidneys independent of C4d. Results are expected to be presented at the 12th Banff meeting to be held in 2013 in Brazil. No change to the Banff classification occurred in 2011. This meeting report summarizes the 11th Banff Conference on Allograft Pathology held in Paris in June 2011, whose major outcome was the acknowledgment of C4d-negative antibody-mediated rejection in kidney transplants.

Original languageEnglish (US)
Pages (from-to)563-570
Number of pages8
JournalAmerican Journal of Transplantation
Volume12
Issue number3
DOIs
StatePublished - Mar 1 2012

Keywords

  • Allograft rejection
  • Banff classification
  • allograft transplantation
  • antibody-mediated rejection

ASJC Scopus subject areas

  • Immunology and Allergy
  • Transplantation
  • Pharmacology (medical)

Fingerprint Dive into the research topics of 'Banff 2011 meeting report: New concepts in antibody-mediated rejection'. Together they form a unique fingerprint.

  • Cite this

    Mengel, M., Sis, B., Haas, M., Colvin, R. B., Halloran, P. F., Racusen, L. C., Solez, K., Cendales, L., Demetris, A. J., Drachenberg, C. B., Farver, C. F., Rodriguez, E. R., Wallace, W. D., & Glotz, D. (2012). Banff 2011 meeting report: New concepts in antibody-mediated rejection. American Journal of Transplantation, 12(3), 563-570. https://doi.org/10.1111/j.1600-6143.2011.03926.x