Balancing instability: Dual roles for telomerase and telomere dysfunction in tumorigenesis

Jennifer A. Hackett, Carol W. Greider

Research output: Contribution to journalReview articlepeer-review

Abstract

Telomere shortening and telomerase activation both occur in human tumors. Telomere shortening has been proposed to have two conflicting roles in tumorigenesis: tumor suppression and initiation of chromosomal instability. Similarly, while telomerase activation is suggested to be necessary for tumor growth, telomerase may help to stabilize genomic instability. Here we review what is known about these conflicting roles and propose a framework to understand the role of telomerase in cancer progression.

Original languageEnglish (US)
Pages (from-to)619-626
Number of pages8
JournalOncogene
Volume21
Issue number4 REV. ISS. 1
DOIs
StatePublished - Jan 21 2002

Keywords

  • Chromosomal instability
  • Telomerase
  • Telomeres

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

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