Balancing instability: Dual roles for telomerase and telomere dysfunction in tumorigenesis

Jennifer A. Hackett, Carol W Greider

Research output: Contribution to journalArticle

Abstract

Telomere shortening and telomerase activation both occur in human tumors. Telomere shortening has been proposed to have two conflicting roles in tumorigenesis: tumor suppression and initiation of chromosomal instability. Similarly, while telomerase activation is suggested to be necessary for tumor growth, telomerase may help to stabilize genomic instability. Here we review what is known about these conflicting roles and propose a framework to understand the role of telomerase in cancer progression.

Original languageEnglish (US)
Pages (from-to)619-626
Number of pages8
JournalOncogene
Volume21
Issue number4 REV. ISS. 1
DOIs
StatePublished - Jan 21 2002

Fingerprint

Telomerase
Telomere
Carcinogenesis
Telomere Shortening
Neoplasms
Chromosomal Instability
Genomic Instability
Growth

Keywords

  • Chromosomal instability
  • Telomerase
  • Telomeres

ASJC Scopus subject areas

  • Molecular Biology
  • Cancer Research
  • Genetics

Cite this

Balancing instability : Dual roles for telomerase and telomere dysfunction in tumorigenesis. / Hackett, Jennifer A.; Greider, Carol W.

In: Oncogene, Vol. 21, No. 4 REV. ISS. 1, 21.01.2002, p. 619-626.

Research output: Contribution to journalArticle

Hackett, Jennifer A. ; Greider, Carol W. / Balancing instability : Dual roles for telomerase and telomere dysfunction in tumorigenesis. In: Oncogene. 2002 ; Vol. 21, No. 4 REV. ISS. 1. pp. 619-626.
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