TY - JOUR
T1 - Balance and imbalance in the immune system
T2 - Life on the edge
AU - Topalian, Suzanne L.
AU - Sharpe, Arlene H.
N1 - Publisher Copyright:
© 2014 Elsevier Inc.
PY - 2014/11/20
Y1 - 2014/11/20
N2 - CTLA-4 is a key immune checkpoint in maintaining self-tolerance, which can be co-opted by cancer to evade immune attack. In Science, Kuehn etal. (2014) describe clinical manifestations from inherited heterozygous CTLA4 mutations, and some are reminiscent of immune-related consequences from anti-CTLA-4 cancer therapy. CTLA-4 is a key immune checkpoint in maintaining self-tolerance, which can be co-opted by cancer to evade immune attack. In Science, Kuehn etal. (2014) describe clinical manifestations from inherited heterozygous CTLA4 mutations, and some are reminiscent of immune-related consequences from anti-CTLA-4 cancer therapy.
AB - CTLA-4 is a key immune checkpoint in maintaining self-tolerance, which can be co-opted by cancer to evade immune attack. In Science, Kuehn etal. (2014) describe clinical manifestations from inherited heterozygous CTLA4 mutations, and some are reminiscent of immune-related consequences from anti-CTLA-4 cancer therapy. CTLA-4 is a key immune checkpoint in maintaining self-tolerance, which can be co-opted by cancer to evade immune attack. In Science, Kuehn etal. (2014) describe clinical manifestations from inherited heterozygous CTLA4 mutations, and some are reminiscent of immune-related consequences from anti-CTLA-4 cancer therapy.
UR - http://www.scopus.com/inward/record.url?scp=84912082792&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84912082792&partnerID=8YFLogxK
U2 - 10.1016/j.immuni.2014.11.005
DO - 10.1016/j.immuni.2014.11.005
M3 - Short survey
C2 - 25517610
AN - SCOPUS:84912082792
SN - 1074-7613
VL - 41
SP - 682
EP - 684
JO - Immunity
JF - Immunity
IS - 5
ER -