TY - JOUR
T1 - Bad bugs, no drugs
T2 - No ESKAPE! An update from the Infectious Diseases Society of America
AU - Boucher, Helen W.
AU - Talbot, George H.
AU - Bradley, John S.
AU - Edwards, John E.
AU - Gilbert, David
AU - Rice, Louis B.
AU - Scheld, Michael
AU - Spellberg, Brad
AU - Bartlett, John
N1 - Funding Information:
Potential conflicts of interest. H.W.B. serves as an advisor or consultant to Astellas, Basilea, Cubist, Johnson & Johnson, Merck, Pfizer, Targanta, and Theravance and has owned shares of Pfizer and Cubist. G.H.T. serves or has recently served as a consultant to Actelion, Bausch and Lomb, Calixa, Cerexa, Cubist, Ipsat, Nabriva, PTC, Rib-X, Shire, Targanta, Tetraphase, Theravance, ViroPharma, and Wyeth. J.S.B.’s employer has received research grants from AstraZeneca, Cubist, Johnson & Johnson, and Wyeth and reimbursement for J.S.B.’s role in consulting for AstraZeneca, Cubist, Johnson & Johnson, Wyeth, Forest/Cerexa, Pfizer, Schering Plough, and Trius. J.E.E. serves on the scientific advisory boards of Pfizer, Merck, and Gilead; has participated in educational programs regarding fungal infections funded by Pfizer, Merck, and Astellas; has received research laboratory support from Pfizer, Merck, and Gilead; and has participated in the Bristol-Myers Squibb Freedom to Discovery research program. D.G. serves as an advisor or consultant to Pfizer, Advanced Life Sciences, Pacific Bioscience, Schering-Plough, Roche, Wyeth, and Pfizer and is on the speakers’ bureau for Merck. L.B.R. serves as a consultant to Advanced Life Sciences, Cadence Novexel Paratek, Pfizer, Johnson & Johnson, and Wyeth; is on the advisory board of Theradoc; and is on the speakers’ bureau for Arpida and Targanta. W.M.S. serves on the advisory board of Pfizer, Cubist, and Glaxo-SmithKline. B.S. has received research support from Astellas, Gilead, Enzon, Novartis, Merck, and Pfizer; serves on the scientific advisory board of Merck; has consulted for Arpida, Basilea, and Cerexa; and owns equity in NovaDigm Therapeutics. J.G.B. serves on the HIV advisory boards for Bristol-Myers Squibb, Abbott Laboratories, and GlaxoSmithKline.
PY - 2009/1/1
Y1 - 2009/1/1
N2 - The Infectious Diseases Society of America (IDSA) continues to view with concern the lean pipeline for novel therapeutics to treat drug-resistant infections, especially those caused by gram-negative pathogens. Infections now occur that are resistant to all current antibacterial options. Although the IDSA is encouraged by the prospect of success for some agents currently in preclinical development, there is an urgent, immediate need for new agents with activity against these panresistant organisms. There is no evidence that this need will be met in the foreseeable future. Furthermore, we remain concerned that the infrastructure for discovering and developing new antibacterials continues to stagnate, thereby risking the future pipeline of antibacterial drugs. The IDSA proposed solutions in its 2004 policy report, "Bad Bugs, No Drugs: As Antibiotic R&D Stagnates, a Public Health Crisis Brews," and recently issued a "Call to Action" to provide an update on the scope of the problem and the proposed solutions. A primary objective of these periodic reports is to encourage a community and legislative response to establish greater financial parity between the antimicrobial development and the development of other drugs. Although recent actions of the Food and Drug Administration and the 110th US Congress present a glimmer of hope, significant uncertainly remains. Now, more than ever, it is essential to create a robust and sustainable antibacterial research and development infrastructure - one that can respond to current antibacterial resistance now and anticipate evolving resistance. This challenge requires that industry, academia, the National Institutes of Health, the Food and Drug Administration, the Centers for Disease Control and Prevention, the US Department of Defense, and the new Biomedical Advanced Research and Development Authority at the Department of Health and Human Services work productively together. This report provides an update on potentially effective antibacterial drugs in the late-stage development pipeline, in the hope of encouraging such collaborative action.
AB - The Infectious Diseases Society of America (IDSA) continues to view with concern the lean pipeline for novel therapeutics to treat drug-resistant infections, especially those caused by gram-negative pathogens. Infections now occur that are resistant to all current antibacterial options. Although the IDSA is encouraged by the prospect of success for some agents currently in preclinical development, there is an urgent, immediate need for new agents with activity against these panresistant organisms. There is no evidence that this need will be met in the foreseeable future. Furthermore, we remain concerned that the infrastructure for discovering and developing new antibacterials continues to stagnate, thereby risking the future pipeline of antibacterial drugs. The IDSA proposed solutions in its 2004 policy report, "Bad Bugs, No Drugs: As Antibiotic R&D Stagnates, a Public Health Crisis Brews," and recently issued a "Call to Action" to provide an update on the scope of the problem and the proposed solutions. A primary objective of these periodic reports is to encourage a community and legislative response to establish greater financial parity between the antimicrobial development and the development of other drugs. Although recent actions of the Food and Drug Administration and the 110th US Congress present a glimmer of hope, significant uncertainly remains. Now, more than ever, it is essential to create a robust and sustainable antibacterial research and development infrastructure - one that can respond to current antibacterial resistance now and anticipate evolving resistance. This challenge requires that industry, academia, the National Institutes of Health, the Food and Drug Administration, the Centers for Disease Control and Prevention, the US Department of Defense, and the new Biomedical Advanced Research and Development Authority at the Department of Health and Human Services work productively together. This report provides an update on potentially effective antibacterial drugs in the late-stage development pipeline, in the hope of encouraging such collaborative action.
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U2 - 10.1086/595011
DO - 10.1086/595011
M3 - Article
C2 - 19035777
AN - SCOPUS:57749107808
SN - 1058-4838
VL - 48
SP - 1
EP - 12
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
IS - 1
ER -