Bacteroides spp. and diarrhea

Elizabeth C. Wick, Cynthia Louise Sears

Research output: Contribution to journalArticle

Abstract

Purpose of review: The purpose of this review is to describe recent progress in the understanding of the role of Bacteroides spp. in human diarrheal diseases and newer murine studies implicating certain Bacteroides spp. in colorectal cancer. Recent findings: Bacteroides fragilis is the only strain of Bacteroides spp. associated with diarrheal disease. Toxin-producing strains of B. fragilis, termed enterotoxigenic Bacteroides fragilis (ETBF), are an established cause of diarrheal disease in people. The clinical syndrome associated with ETBF diarrheal disease encompasses abdominal pain, tenesmus and inflammatory diarrhea. Two new studies conducted in mice have further defined the chronic inflammatory response associated with ETBF infection and observed that in the multiple intestinal neoplasia mouse strain, heterozygotes for the adenomatous polyposis coli gene, ETBF infection enhances development of colonic tumors. Separate murine studies have begun to define the role of nontoxin-producing B. fragilis as a symbiont, serving possibly to protect the host from colonic inflammation. Summary: B. fragilis remains the leading anaerobe in human disease. ETBF is emerging as an important cause of human diarrheal disease but additional epidemiologic studies are needed to better understand the role of ETBF human disease.

Original languageEnglish (US)
Pages (from-to)470-474
Number of pages5
JournalCurrent Opinion in Infectious Diseases
Volume23
Issue number5
DOIs
StatePublished - Oct 2010

Fingerprint

Bacteroides fragilis
Bacteroides
Diarrhea
Bacteroides Infections
APC Genes
Heterozygote
Abdominal Pain
Epidemiologic Studies
Colorectal Neoplasms
Neoplasms
Inflammation

Keywords

  • Bacteroides
  • diarrhea
  • enterotoxigenic Bacteroides fragilis

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

Cite this

Bacteroides spp. and diarrhea. / Wick, Elizabeth C.; Sears, Cynthia Louise.

In: Current Opinion in Infectious Diseases, Vol. 23, No. 5, 10.2010, p. 470-474.

Research output: Contribution to journalArticle

Wick, Elizabeth C. ; Sears, Cynthia Louise. / Bacteroides spp. and diarrhea. In: Current Opinion in Infectious Diseases. 2010 ; Vol. 23, No. 5. pp. 470-474.
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