Bacterial penetration across the blood-brain barrier during the development of neonatal meningitis

Research output: Contribution to journalReview article

Abstract

Bacterial pathogens may breach the blood-brain barrier (BBB) and invade the central nervous system through paracellular and/or transcellular mechanisms. Transcellular penetration, e.g., transcytosis across the BBB has been demonstrated for Escherichia coli K1, group B streptococcus, Listeria monocytogenes, Citrobacter freundii and Streptococcus pneumonia strains. Genes contributing to invasion of brain microvascular endothelial cells include E. coli K1 genes ompA, ibeA, ibeB, and yijP. Understanding the mechanisms of bacterial penetration across the BBB may help develop novel approaches to preventing bacterial meningitis. (C) 2000 Editions scientifiques et medicales Elsevier SAS.

Original languageEnglish (US)
Pages (from-to)1237-1244
Number of pages8
JournalMicrobes and Infection
Volume2
Issue number10
DOIs
StatePublished - Jan 1 2000
Externally publishedYes

Keywords

  • Blood-brain barrier
  • IbeA
  • IbeB
  • Meningitic bacteria
  • Meningitis
  • OmpA
  • PAF
  • Receptors
  • Transcytosis
  • YijP

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Infectious Diseases

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