Bacterial natural products in the fight against mosquito-transmitted tropical diseases

Raúl G. Saraiva, George Dimopoulos

Research output: Contribution to journalReview articlepeer-review

Abstract

Covering: up to 2019 Secondary metabolites of microbial origin have long been acknowledged as medically relevant, but their full potential remains largely unexploited. Of the countless natural compounds discovered thus far, only 5-10% have been isolated from microorganisms. At the same time, while whole-genome sequencing has demonstrated that bacteria and fungi often encode natural products, only a few genera have yet been mined for new compounds. This review explores the contributions of bacterial natural products to combatting infection by malaria parasites, filarial worms, and arboviruses such as dengue, Zika, Chikungunya, and West Nile. It highlights how molecules isolated from microorganisms ranging from marine cyanobacteria to mosquito endosymbionts can be exploited as antimicrobials and antivirals. Pursuit of this mostly untapped source of chemical entities will potentially result in new interventions against these tropical diseases, which are urgently needed to combat the increase in the incidence of resistance.

Original languageEnglish (US)
Pages (from-to)338-354
Number of pages17
JournalNatural Product Reports
Volume37
Issue number3
DOIs
StatePublished - Mar 2020

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

Fingerprint Dive into the research topics of 'Bacterial natural products in the fight against mosquito-transmitted tropical diseases'. Together they form a unique fingerprint.

Cite this