Bacterial infections

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Bacterial skin infections are a major cause of morbidity and mortality and consequently exert a significant medical and economic burden on healthcare resources. In an era of declining antimicrobial drug development and rising antibiotic resistance among clinical bacterial isolates, there are serious concerns that current antibiotic therapy will not provide a durable solution to this public health threat. If future immune-based therapies are to provide an alternative or complementary therapy to antibiotics, a greater understanding of the key innate and adaptive cutaneous immune responses provide host defense bacterial skin infections is essential. This chapter focuses on the host defense mechanisms against two of the most common bacterial skin pathogens, Staphylococcus aureus (S. aureus) and group A Streptococcus.

Original languageEnglish (US)
Title of host publicationClinical and Basic Immunodermatology
Subtitle of host publicationSecond Edition
PublisherSpringer International Publishing
Pages265-288
Number of pages24
ISBN (Electronic)9783319297859
ISBN (Print)9783319297835
DOIs
StatePublished - Apr 24 2017

Keywords

  • Adaptive immunity
  • Antimicrobial peptides
  • Group A Streptococcus
  • Inflammasome
  • Innate immunity
  • Pattern recognition receptors
  • Staphylococcus aureus
  • Streptococcus pyogenes
  • Toll-like receptors

ASJC Scopus subject areas

  • Medicine(all)
  • Immunology and Microbiology(all)

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