Abstract
Bacterial skin infections are a major cause of morbidity and mortality and consequently exert a significant medical and economic burden on healthcare resources. In an era of declining antimicrobial drug development and rising antibiotic resistance among clinical bacterial isolates, there are serious concerns that current antibiotic therapy will not provide a durable solution to this public health threat. If future immune-based therapies are to provide an alternative or complementary therapy to antibiotics, a greater understanding of the key innate and adaptive cutaneous immune responses provide host defense bacterial skin infections is essential. This chapter focuses on the host defense mechanisms against two of the most common bacterial skin pathogens, Staphylococcus aureus (S. aureus) and group A Streptococcus.
Original language | English (US) |
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Title of host publication | Clinical and Basic Immunodermatology |
Subtitle of host publication | Second Edition |
Publisher | Springer International Publishing |
Pages | 265-288 |
Number of pages | 24 |
ISBN (Electronic) | 9783319297859 |
ISBN (Print) | 9783319297835 |
DOIs | |
State | Published - Apr 24 2017 |
Keywords
- Adaptive immunity
- Antimicrobial peptides
- Group A Streptococcus
- Inflammasome
- Innate immunity
- Pattern recognition receptors
- Staphylococcus aureus
- Streptococcus pyogenes
- Toll-like receptors
ASJC Scopus subject areas
- General Medicine
- General Immunology and Microbiology