Innate immune responses are directed against conserved components of microorganisms called pathogen-associated molecular patterns (PAMPs). The host cellular receptors that recognize different PAMPs are called pattern recognition receptors (PRRs). Two major families of human antimicrobial peptides are defensins and cathelicidin. Toll-like receptors (TLRs) are important PRRs involved in host defense against a variety of pathogenic microorganisms. Complement plays a key role in killing of bacteria. Neutrophils, monocytes, and macrophages phagocytose opsonized bacteria.
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