Bacterial infection is not necessary for lethal necrotizing pancreatitis in mice

David W. Rattner, Carolyn C. Compton, Zhuo Yun Gu, Robert Wilkinson, Andrew L. Warshaw

Research output: Contribution to journalArticle

Abstract

Sepsis is the most comon cause of late death in pancreatitis. The presence of early bacterial infection has been correlated with the severity of the disease. A choline-deficient ethionine-supplemented (CDE) diet given to young female mice produces severe necrotizing pancreatitis that has morphologic and biochemical similarities to the human disease. We therefore searched for bacterial pancreatic infection in female CD-1 mice given the CDE diet. The mortality rate was 47.5% in mice fed the CDE diet. All of these mice had severe pancreatitis with inflammation, edema, and necrosis on histologic examination. Bacterial infection was present in 1/12 pancreatica among nonsurvivors and in 1/32 pancreatica in surviving animals (p not significant). Histologic examination showed edema to be more pronouced in surviving mice, although the overall seventy of morphologic changes was not significantly different between survivors and nonsurvivors. We conclude that bacterial infection is not a determinant of the severity or lethality of experimental pancreatitis induced by the CDE diet.

Original languageEnglish (US)
Pages (from-to)99-105
Number of pages7
JournalInternational Journal of Pancreatology
Volume5
Issue number1
DOIs
StatePublished - Jul 1989
Externally publishedYes

Keywords

  • Experimental pancreatitis
  • infected necrosis
  • pancreatic asscess
  • pancreatic infection

ASJC Scopus subject areas

  • Oncology
  • Gastroenterology
  • Endocrinology

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