Baclofen inhibits sympathetic preganglionic neurons in an isolated spinal cord preparation

Kevin E. McKenna; Lawrence P. Schramm

doi:10.1016/0304-3940(84)90391-4

Baclofen inhibits sympathetic preganglionic neurons in an isolated spinal cord preparation

Kevin E. McKenna, Lawrence P. Schramm

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

The effects of the antispastic drug, baclofen, were examined in sympathetic preganglionic neurons (PGNs) recorded in the isolated spinal cord of the neonatal rat. Addition of 10^-5 M baclofen to the superfusion medium inhibited the activation of PGNs by dorsal root stimulation in 96% of the neurons tested. The time course of inhibition of sympathetic reflexes paralleled the inhibition of ventral root (primarily somatic) reflexes evoked by the same stimulus. Spontaneous activity was abolished by baclofen in 69% of the spontaneously active PGNs tested. It is concluded that baclofen has a powerful sympatho-inhibitory effect at the spinal level.

Original language	English (US)
Pages (from-to)	85-88
Number of pages	4
Journal	Neuroscience Letters
Volume	47
Issue number	1
DOIs	https://doi.org/10.1016/0304-3940(84)90391-4
State	Published - Jun 1 1984
Externally published	Yes

Keywords

baclofen
neonatal rat
spinal cord
sympathetic preganglionic neurons

ASJC Scopus subject areas

General Neuroscience

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10.1016/0304-3940(84)90391-4

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title = "Baclofen inhibits sympathetic preganglionic neurons in an isolated spinal cord preparation",

abstract = "The effects of the antispastic drug, baclofen, were examined in sympathetic preganglionic neurons (PGNs) recorded in the isolated spinal cord of the neonatal rat. Addition of 10-5 M baclofen to the superfusion medium inhibited the activation of PGNs by dorsal root stimulation in 96% of the neurons tested. The time course of inhibition of sympathetic reflexes paralleled the inhibition of ventral root (primarily somatic) reflexes evoked by the same stimulus. Spontaneous activity was abolished by baclofen in 69% of the spontaneously active PGNs tested. It is concluded that baclofen has a powerful sympatho-inhibitory effect at the spinal level.",

keywords = "baclofen, neonatal rat, spinal cord, sympathetic preganglionic neurons",

author = "McKenna, {Kevin E.} and Schramm, {Lawrence P.}",

note = "Funding Information: Ciba-Geigy generously supplied the baclofen (Lioresal). We thank Ms. Evelyn McCann for processing the manuscript. This research was supported by N.I.H. Research Grant HL16315 and N.I.H. Training Grant GM07057.",

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journal = "Neuroscience Letters",

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T1 - Baclofen inhibits sympathetic preganglionic neurons in an isolated spinal cord preparation

AU - McKenna, Kevin E.

AU - Schramm, Lawrence P.

N1 - Funding Information: Ciba-Geigy generously supplied the baclofen (Lioresal). We thank Ms. Evelyn McCann for processing the manuscript. This research was supported by N.I.H. Research Grant HL16315 and N.I.H. Training Grant GM07057.

PY - 1984/6/1

Y1 - 1984/6/1

N2 - The effects of the antispastic drug, baclofen, were examined in sympathetic preganglionic neurons (PGNs) recorded in the isolated spinal cord of the neonatal rat. Addition of 10-5 M baclofen to the superfusion medium inhibited the activation of PGNs by dorsal root stimulation in 96% of the neurons tested. The time course of inhibition of sympathetic reflexes paralleled the inhibition of ventral root (primarily somatic) reflexes evoked by the same stimulus. Spontaneous activity was abolished by baclofen in 69% of the spontaneously active PGNs tested. It is concluded that baclofen has a powerful sympatho-inhibitory effect at the spinal level.

AB - The effects of the antispastic drug, baclofen, were examined in sympathetic preganglionic neurons (PGNs) recorded in the isolated spinal cord of the neonatal rat. Addition of 10-5 M baclofen to the superfusion medium inhibited the activation of PGNs by dorsal root stimulation in 96% of the neurons tested. The time course of inhibition of sympathetic reflexes paralleled the inhibition of ventral root (primarily somatic) reflexes evoked by the same stimulus. Spontaneous activity was abolished by baclofen in 69% of the spontaneously active PGNs tested. It is concluded that baclofen has a powerful sympatho-inhibitory effect at the spinal level.

KW - baclofen

KW - neonatal rat

KW - spinal cord

KW - sympathetic preganglionic neurons

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Baclofen inhibits sympathetic preganglionic neurons in an isolated spinal cord preparation

Abstract

Keywords

ASJC Scopus subject areas

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