@article{4ca3fc94746348c7938d5deede41b1e9,
title = "Backbone chemical shift assignment of macrophage infectivity potentiator virulence factor of Trypanosoma cruzi",
abstract = " Chagas disease is a trypanosomiasis disease inflicted by Trypanosoma cruzi parasite. In Latin America, at least 10 million people are infected and annually, 10,000 casualties are deplored. Macrophage infectivity potentiator protein is one of the major virulence factors secreted by T. cruzi (TcMIP) in order to infect its host but little is known about its mechanism of action. Studies confer TcMIP an important role in the extracellular matrix transmigration and basal lamina penetration. Here, we report the backbone 1 H, 13 C, and 15 N resonance assignment of TcMIP and the comparison of the secondary structure obtained against reported X-ray crystallography data.",
keywords = "FK506 binding protein, FKBP-like protein, Macrophage infectivity potentiator, NMR resonance assignment, Prolyl cis trans isomerase, TcMIP, Trypanosoma cruzi, Virulence factor",
author = "Lopez, {Juan M.} and Ricardo Antiparra and Guy lippens and Mirko Zimic and Patricia Sheen and Helena Maruenda",
note = "Funding Information: Fig. 3 Left, TcMIP X-ray structure (PDB: 1JVW), label in red unassigned residues. Right, plot of assigned chemical shift vs. predicted chemical shift. Predicted shifts were obtained from X-ray structure (PDB: 1JVW) using SHIFTX2 (Han et al. 2011) Acknowledgements This work was funded by ICGEB early career grant (CRP/PER16-05-EC), Consorcio de Universidades (PIIM-2016), Programa Inn{\'o}vate Per{\'u} del Ministerio de la Producci{\'o}n (203-INNOVATEPERU-EC-2016) and Cienciactiva - CONCYTEC (008-2017-FONDECYT). NMR access to the 800MHz spectrometer was granted by MetaToul (Toulouse metabolomics & fluxomics facilities, www.metatoul.fr) as part of the French National Infrastructure for Metabolomics and Fluxomics MetaboHUBAR-11-INBS-0010 (www.metabohub.fr), supported by the R{\'e}gion Occitanie, the ERDF, the SICOVAL, and the French Minister of Education & Research. Funding Information: This work was funded by ICGEB early career grant (CRP/PER16-05-EC), Consorcio de Universidades (PIIM-2016), Programa Inn?vate Per? del Ministerio de la Producci?n (203-INNOVATEPERU-EC-2016) and Cienciactiva - CONCYTEC (008-2017-FONDECYT).?NMR access to the 800MHz spectrometer was granted by MetaToul (Toulouse metabolomics & fluxomics facilities, www.metatoul.fr) as part of the French National Infrastructure for Metabolomics and Fluxomics MetaboHUBAR- 11-INBS-0010 (www.metabohub.fr), supported by the Re?gion Occitanie, the ERDF, the SICOVAL, and the French Minister of Education & Research. Publisher Copyright: {\textcopyright} 2018, Springer Nature B.V.",
year = "2019",
month = apr,
day = "1",
doi = "10.1007/s12104-018-9844-1",
language = "English (US)",
volume = "13",
pages = "21--25",
journal = "Biomolecular NMR Assignments",
issn = "1874-2718",
publisher = "Springer Netherlands",
number = "1",
}