Back in the water: The return of the inositol phosphates

Robin F. Irvine, Michael J. Schell

Research output: Contribution to journalArticle

Abstract

Following the discovery of inositol-1,4,5-trisphosphate as a second messenger, many other inositol phosphates were discovered in quick succession, with some understanding of their synthesis pathways and a few guesses at their possible functions. But then it all seemed to go comparatively quiet, with an explosion of interest in the inositol lipids. Now the water-soluble phase is once again becoming a focus of interest. Old and new data point to a new vista of inositol phosphates, with functions in many diverse aspects of cell biology, such as ion-channel physiology, membrane dynamics and nuclear signalling.

Original languageEnglish (US)
Pages (from-to)327-338
Number of pages12
JournalNature Reviews Molecular Cell Biology
Volume2
Issue number5
DOIs
StatePublished - May 2001
Externally publishedYes

Fingerprint

Inositol Phosphates
Inositol 1,4,5-Trisphosphate
Explosions
Water
Nuclear Envelope
Second Messenger Systems
Inositol
Ion Channels
Cell Biology
Lipids

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology

Cite this

Back in the water : The return of the inositol phosphates. / Irvine, Robin F.; Schell, Michael J.

In: Nature Reviews Molecular Cell Biology, Vol. 2, No. 5, 05.2001, p. 327-338.

Research output: Contribution to journalArticle

Irvine, Robin F. ; Schell, Michael J. / Back in the water : The return of the inositol phosphates. In: Nature Reviews Molecular Cell Biology. 2001 ; Vol. 2, No. 5. pp. 327-338.
@article{64eb49b77cf8465097866bbd699a4399,
title = "Back in the water: The return of the inositol phosphates",
abstract = "Following the discovery of inositol-1,4,5-trisphosphate as a second messenger, many other inositol phosphates were discovered in quick succession, with some understanding of their synthesis pathways and a few guesses at their possible functions. But then it all seemed to go comparatively quiet, with an explosion of interest in the inositol lipids. Now the water-soluble phase is once again becoming a focus of interest. Old and new data point to a new vista of inositol phosphates, with functions in many diverse aspects of cell biology, such as ion-channel physiology, membrane dynamics and nuclear signalling.",
author = "Irvine, {Robin F.} and Schell, {Michael J.}",
year = "2001",
month = "5",
doi = "10.1038/35073015",
language = "English (US)",
volume = "2",
pages = "327--338",
journal = "Nature Reviews Molecular Cell Biology",
issn = "1471-0072",
publisher = "Nature Publishing Group",
number = "5",

}

TY - JOUR

T1 - Back in the water

T2 - The return of the inositol phosphates

AU - Irvine, Robin F.

AU - Schell, Michael J.

PY - 2001/5

Y1 - 2001/5

N2 - Following the discovery of inositol-1,4,5-trisphosphate as a second messenger, many other inositol phosphates were discovered in quick succession, with some understanding of their synthesis pathways and a few guesses at their possible functions. But then it all seemed to go comparatively quiet, with an explosion of interest in the inositol lipids. Now the water-soluble phase is once again becoming a focus of interest. Old and new data point to a new vista of inositol phosphates, with functions in many diverse aspects of cell biology, such as ion-channel physiology, membrane dynamics and nuclear signalling.

AB - Following the discovery of inositol-1,4,5-trisphosphate as a second messenger, many other inositol phosphates were discovered in quick succession, with some understanding of their synthesis pathways and a few guesses at their possible functions. But then it all seemed to go comparatively quiet, with an explosion of interest in the inositol lipids. Now the water-soluble phase is once again becoming a focus of interest. Old and new data point to a new vista of inositol phosphates, with functions in many diverse aspects of cell biology, such as ion-channel physiology, membrane dynamics and nuclear signalling.

UR - http://www.scopus.com/inward/record.url?scp=0035347166&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035347166&partnerID=8YFLogxK

U2 - 10.1038/35073015

DO - 10.1038/35073015

M3 - Article

C2 - 11331907

AN - SCOPUS:0035347166

VL - 2

SP - 327

EP - 338

JO - Nature Reviews Molecular Cell Biology

JF - Nature Reviews Molecular Cell Biology

SN - 1471-0072

IS - 5

ER -