Bacillary Layer Detachment in Bilateral Diffuse Uveal Melanocytic Proliferation Masquerading as Neovascular AMD

Mark P. Breazzano, Tommaso Bacci, Hao Wang, Jasmine H. Francis, Lawrence A. Yannuzzi

Research output: Contribution to journalArticlepeer-review

Abstract

Bilateral diffuse uveal melanocytic proliferation (BDUMP) is a rare and unusual paraneoplastic ocular syndrome with generally poor prognosis. The authors present a case of BDUMP in a patient with bladder cancer, examined with current multimodal imaging. In the clinical setting with drusen and exudative macular detachments, the fundus simulated neovascular age-related macular degeneration, warranting standard-of-care therapy. The imaging actually showed the typical manifestations of BDUMP, but also newly recognized, associated manifestations, including the bacillary layer detachment, a gravitating retinal detachment, and multifocal choroidal hyperpermeability, but no evidence of neovascularization. Recognition of these associated manifestations is of value in appreciating the pathophysiology of this paraneoplastic disorder. Based on the imaging, the correct diagnosis was possible along with a better understanding of the nature of the clinical features in the posterior fundus.

Original languageEnglish (US)
Pages (from-to)413-417
Number of pages5
JournalOphthalmic Surgery Lasers and Imaging Retina
Volume51
Issue number7
DOIs
StatePublished - Jul 2020

ASJC Scopus subject areas

  • Surgery
  • Ophthalmology

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