B7-Negative Versus B7-Positive P815 Tumor: Differential Requirements for Priming of an Antitumor Immune Response in Lymph Nodes

Guchen Yang, Mark T. Mizuno, Karl Erik Hellström, Lieping Chen

Research output: Contribution to journalArticle

Abstract

Efficient T cell activation requires two synergistic but distinct signals derived from antigenic peptides presented by the MHC and from costimulatory molecules, particularly those belonging to the B7 family. Lack of B7-CD28 interaction may cause unresponsiveness of T cells to subsequent exposure to Ag. Nevertheless, immunization by some B7- tumors induces an antitumor immune response. We found that the immune response against two B7- tumors, the mouse P815 mastocytoma and the E7C3 melanoma, requires host-derived B7, since blockage of the B7-CD28 interaction facilitates tumor growth and eliminates an antitumor response. B7 costimulation is provided in the regional, tumor-draining lymph nodes for the induction of a primary CTL response against both B7+ tumor and B7- tumor. However, the induction of a CTL response to B7+ tumors and its clonal expansion may occur at tumor sites in addition to secondary lymphoid organs so as to generate more effective tumor immunity.

Original languageEnglish (US)
Pages (from-to)851-858
Number of pages8
JournalJournal of Immunology
Volume158
Issue number2
Publication statusPublished - Jan 15 1997
Externally publishedYes

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ASJC Scopus subject areas

  • Immunology

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