B7-H4, a Molecule of the B7 Family, Negatively Regulates T Cell Immunity

Gabriel L. Sica, In Hak Choi, Gefeng Zhu, Koji Tamada, Sheng Dian Wang, Hideto Tamura, Andrei I. Chapoval, Dallas B. Flies, Jürgen Bajorath, Lieping Chen

Research output: Contribution to journalArticlepeer-review

Abstract

We identify a B7 family molecule, B7-H4, by protein sequence analysis and comparative molecular modeling. While B7-H4 mRNA is widely distributed in mouse and human peripheral tissues, cell surface expression of B7-H4 protein is limited and shows an inducible pattern on hematopoietic cells. Putative receptor of B7-H4 can be upregulated on activated T cells. By arresting cell cycle, B7-H4 ligation of T cells has a profound inhibitory effect on the growth, cytokine secretion, and development of cytotoxicity. Administration of B7-H4Ig into mice impairs antigen-specific T cell responses whereas blockade of endogenous B7-H4 by specific monoclonal antibody promotes T cell responses. B7-H4 thus may participate in negative regulation of cell-mediated immunity in peripheral tissues.

Original languageEnglish (US)
Pages (from-to)849-861
Number of pages13
JournalImmunity
Volume18
Issue number6
DOIs
StatePublished - Jun 1 2003
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases
  • Immunology

Fingerprint Dive into the research topics of 'B7-H4, a Molecule of the B7 Family, Negatively Regulates T Cell Immunity'. Together they form a unique fingerprint.

Cite this