B7-H1 is up-regulated in HIV infection and is a novel surrogate marker of disease progression

Daria Trabattoni, Marina Saresella, Mara Biasin, Adriano Boasso, Luca Piacentini, Pasquale Ferrante, Haidong Dong, Renato Maserati, Gene M. Shearer, Lieping Chen, Mario Clerici

Research output: Contribution to journalArticle

Abstract

The ligation of programmed death-ligand I (B7-H1) to T cells results in the preferential production of interleukin 10 (IL-10). We investigated if B7-H1 would be up-regulated in HIV infection, a disease characterized by increased IL-10 production, by measuring B7-H1, B7-1 (CD80), and B7-2 (CD86) expression and mRNA in 36 HIV-infected patients and in 22 healthy controls (HCs). Results showed that (1) B7-H1 expression and mRNA are augmented in cells of HIV patients; (2) increased IL-10 production in these patients is largely induced by B7-H1-expressing CD14+ cells; (3) an inverse correlation is detected between B7-H1 expression and CD4 counts, whereas the up-regulation of B7-H1 is directly associated with HIV plasma viremia; (4) antiviral therapy results in the parallel down modulation of IL-10 production and B7-H1 expression/ synthesis; and (5) B7-H1/CD80 and B7-H1/ CD86 mRNA ratios are increased in peripheral blood mononuclear cells (PBMCs) of HIV patients compared with HCs. B7-H1 synthesis and expression are up-regulated in HIV infection, and the degree of dysregulation correlates with the severity of disease. Aberrant antigen presentation by antigen-presenting cells (APCs) that exhibit increased B7-H1 expression and IL-10 production in HIV infection could be responsible for T-lymphocyte unresponsiveness and loss of protective immunity. B7-H1 is a surrogate marker potentially involved in AIDS disease progression.

Original languageEnglish (US)
Pages (from-to)2514-2520
Number of pages7
JournalBlood
Volume101
Issue number7
DOIs
StatePublished - Apr 1 2003
Externally publishedYes

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ASJC Scopus subject areas

  • Hematology

Cite this

Trabattoni, D., Saresella, M., Biasin, M., Boasso, A., Piacentini, L., Ferrante, P., Dong, H., Maserati, R., Shearer, G. M., Chen, L., & Clerici, M. (2003). B7-H1 is up-regulated in HIV infection and is a novel surrogate marker of disease progression. Blood, 101(7), 2514-2520. https://doi.org/10.1182/blood-2002-10-3065