TY - JOUR
T1 - B7-H1 determines accumulation and deletion of intrahepatic CD8+ T lymphocytes
AU - Dong, Haidong
AU - Zhu, Gefeng
AU - Tamada, Koji
AU - Flies, Dallas B.
AU - Van Deursen, Jan M A
AU - Chen, Lieping
PY - 2004/3
Y1 - 2004/3
N2 - Upon systemic activation by antigens, CD8+, but not CD4 +, T cells selectively accumulate and undergo apoptosis in the liver, a mechanism associated with the induction of hepatic tolerance and chronic infection. The molecular basis for CD8+ T cell preference in this process is unknown. We prepared B7-H1-deficient mice by gene targeting and found spontaneous accumulation of CD8+ T cells in the liver while CD4+ T cell levels remained normal. Moreover, antigen-driven CD8 + T cells proliferated normally while apoptotic levels during the contraction phase was selectively impaired in the liver, leading to accelerated hepatocyte damage in experimental autoimmune hepatitis. Therefore, B7-H1 is a key protein selectively regulating the accumulation and deletion of intrahepatic CD8+ T cells and may also contribute to inflammation, autoimmune diseases, and tolerance in the liver.
AB - Upon systemic activation by antigens, CD8+, but not CD4 +, T cells selectively accumulate and undergo apoptosis in the liver, a mechanism associated with the induction of hepatic tolerance and chronic infection. The molecular basis for CD8+ T cell preference in this process is unknown. We prepared B7-H1-deficient mice by gene targeting and found spontaneous accumulation of CD8+ T cells in the liver while CD4+ T cell levels remained normal. Moreover, antigen-driven CD8 + T cells proliferated normally while apoptotic levels during the contraction phase was selectively impaired in the liver, leading to accelerated hepatocyte damage in experimental autoimmune hepatitis. Therefore, B7-H1 is a key protein selectively regulating the accumulation and deletion of intrahepatic CD8+ T cells and may also contribute to inflammation, autoimmune diseases, and tolerance in the liver.
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U2 - 10.1016/S1074-7613(04)00050-0
DO - 10.1016/S1074-7613(04)00050-0
M3 - Article
C2 - 15030776
AN - SCOPUS:1642306942
SN - 1074-7613
VL - 20
SP - 327
EP - 336
JO - Immunity
JF - Immunity
IS - 3
ER -