B7-H1 determines accumulation and deletion of intrahepatic CD8+ T lymphocytes

Haidong Dong, Gefeng Zhu, Koji Tamada, Dallas B. Flies, Jan M A Van Deursen, Lieping Chen

Research output: Contribution to journalArticle

Abstract

Upon systemic activation by antigens, CD8+, but not CD4 +, T cells selectively accumulate and undergo apoptosis in the liver, a mechanism associated with the induction of hepatic tolerance and chronic infection. The molecular basis for CD8+ T cell preference in this process is unknown. We prepared B7-H1-deficient mice by gene targeting and found spontaneous accumulation of CD8+ T cells in the liver while CD4+ T cell levels remained normal. Moreover, antigen-driven CD8 + T cells proliferated normally while apoptotic levels during the contraction phase was selectively impaired in the liver, leading to accelerated hepatocyte damage in experimental autoimmune hepatitis. Therefore, B7-H1 is a key protein selectively regulating the accumulation and deletion of intrahepatic CD8+ T cells and may also contribute to inflammation, autoimmune diseases, and tolerance in the liver.

Original languageEnglish (US)
Pages (from-to)327-336
Number of pages10
JournalImmunity
Volume20
Issue number3
DOIs
StatePublished - Mar 2004
Externally publishedYes

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T-Lymphocytes
Liver
CD8 Antigens
Autoimmune Hepatitis
Gene Targeting
Autoimmune Diseases
Hepatocytes
Apoptosis
Inflammation
Infection
Proteins

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases
  • Immunology

Cite this

Dong, H., Zhu, G., Tamada, K., Flies, D. B., Van Deursen, J. M. A., & Chen, L. (2004). B7-H1 determines accumulation and deletion of intrahepatic CD8+ T lymphocytes. Immunity, 20(3), 327-336. https://doi.org/10.1016/S1074-7613(04)00050-0

B7-H1 determines accumulation and deletion of intrahepatic CD8+ T lymphocytes. / Dong, Haidong; Zhu, Gefeng; Tamada, Koji; Flies, Dallas B.; Van Deursen, Jan M A; Chen, Lieping.

In: Immunity, Vol. 20, No. 3, 03.2004, p. 327-336.

Research output: Contribution to journalArticle

Dong, H, Zhu, G, Tamada, K, Flies, DB, Van Deursen, JMA & Chen, L 2004, 'B7-H1 determines accumulation and deletion of intrahepatic CD8+ T lymphocytes', Immunity, vol. 20, no. 3, pp. 327-336. https://doi.org/10.1016/S1074-7613(04)00050-0
Dong H, Zhu G, Tamada K, Flies DB, Van Deursen JMA, Chen L. B7-H1 determines accumulation and deletion of intrahepatic CD8+ T lymphocytes. Immunity. 2004 Mar;20(3):327-336. https://doi.org/10.1016/S1074-7613(04)00050-0
Dong, Haidong ; Zhu, Gefeng ; Tamada, Koji ; Flies, Dallas B. ; Van Deursen, Jan M A ; Chen, Lieping. / B7-H1 determines accumulation and deletion of intrahepatic CD8+ T lymphocytes. In: Immunity. 2004 ; Vol. 20, No. 3. pp. 327-336.
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