B7-H1-dependent sex-related differences in tumor immunity and immunotherapy responses

Pei Yi Lin, Lishi Sun, Suzanne R. Thibodeaux, Sara M. Ludwig, Ratna K. Vadlamudi, Vincent J. Hurez, Rumana Bahar, Mark J. Kious, Carolina B. Livi, Shawna R. Wall, Lieping Chen, Bin Zhang, Tahiro Shin, Tyler J. Curiel

Research output: Contribution to journalArticle

Abstract

CD4+CD25+Foxp3+ regulatory T cells (Tregs) are immunopathogenic in cancers by impeding tumor-specific immunity. B7-homologue 1 (B7-H1) (CD274) is a cosignaling molecule with pleiotropic effects, including hindering antitumor immunity. In this study, we demonstrate sex-dependent, B7-H1-dependent differences in tumor immunity and response to immunotherapy in a hormone-independent cancer, murine B16 melanoma. Antitumor immunity was better in B7-H1-/- females versus males as a result of reduced regulatory T cell function in the B7-H1-/- females, and clinical response following B7-H1 blockade as tumor immunotherapy was significantly better in wild-type females than in males, owing to greater B7-H1 blockade-mediated reduction of Treg function in females. Wild-type female Tregs expressed significantly lower B7-H1 versus males but were insensitive to estrogen in vitro. Female B7-H1-/- Tregs were exquisitely sensitive to estrogen-mediated functional reduction in vitro, suggesting that B7-H1 effects occur before terminal Treg differentiation. Immune differences were independent of known B7-H1 ligands. Sex-dependent immune differences are seldom considered in designing immune therapy or interpreting immunotherapy treatment results. Our data demonstrate that sex is an important variable in tumor immunopathogenesis and immunotherapy responses through differential Treg function and B7-H1 signaling.

Original languageEnglish (US)
Pages (from-to)2747-2753
Number of pages7
JournalJournal of Immunology
Volume185
Issue number5
DOIs
StatePublished - Sep 1 2010

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Sex Characteristics
Immunotherapy
Immunity
Neoplasms
Regulatory T-Lymphocytes
Estrogens
CD80 Antigens
Experimental Melanomas
Hormones
Therapeutics
In Vitro Techniques

ASJC Scopus subject areas

  • Immunology
  • Medicine(all)

Cite this

Lin, P. Y., Sun, L., Thibodeaux, S. R., Ludwig, S. M., Vadlamudi, R. K., Hurez, V. J., ... Curiel, T. J. (2010). B7-H1-dependent sex-related differences in tumor immunity and immunotherapy responses. Journal of Immunology, 185(5), 2747-2753. https://doi.org/10.4049/jimmunol.1000496

B7-H1-dependent sex-related differences in tumor immunity and immunotherapy responses. / Lin, Pei Yi; Sun, Lishi; Thibodeaux, Suzanne R.; Ludwig, Sara M.; Vadlamudi, Ratna K.; Hurez, Vincent J.; Bahar, Rumana; Kious, Mark J.; Livi, Carolina B.; Wall, Shawna R.; Chen, Lieping; Zhang, Bin; Shin, Tahiro; Curiel, Tyler J.

In: Journal of Immunology, Vol. 185, No. 5, 01.09.2010, p. 2747-2753.

Research output: Contribution to journalArticle

Lin, PY, Sun, L, Thibodeaux, SR, Ludwig, SM, Vadlamudi, RK, Hurez, VJ, Bahar, R, Kious, MJ, Livi, CB, Wall, SR, Chen, L, Zhang, B, Shin, T & Curiel, TJ 2010, 'B7-H1-dependent sex-related differences in tumor immunity and immunotherapy responses', Journal of Immunology, vol. 185, no. 5, pp. 2747-2753. https://doi.org/10.4049/jimmunol.1000496
Lin PY, Sun L, Thibodeaux SR, Ludwig SM, Vadlamudi RK, Hurez VJ et al. B7-H1-dependent sex-related differences in tumor immunity and immunotherapy responses. Journal of Immunology. 2010 Sep 1;185(5):2747-2753. https://doi.org/10.4049/jimmunol.1000496
Lin, Pei Yi ; Sun, Lishi ; Thibodeaux, Suzanne R. ; Ludwig, Sara M. ; Vadlamudi, Ratna K. ; Hurez, Vincent J. ; Bahar, Rumana ; Kious, Mark J. ; Livi, Carolina B. ; Wall, Shawna R. ; Chen, Lieping ; Zhang, Bin ; Shin, Tahiro ; Curiel, Tyler J. / B7-H1-dependent sex-related differences in tumor immunity and immunotherapy responses. In: Journal of Immunology. 2010 ; Vol. 185, No. 5. pp. 2747-2753.
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