B7-H1 (CD274) inhibits the development of herpetic stromal keratitis (HSK)

Her Jun, Su K. Seo, Hye Young Jeong, Hyoun Mi Seo, Gefeng Zhu, Lieping Chen, In Hak Choi

Research output: Contribution to journalArticle

Abstract

The co-signaling molecule B7-H1 (CD274) functions as both a co-inhibitor through programmed death-1 (PD-1) receptor and a co-stimulator via an as-yet-unidentified receptor on T cells. We investigated the physiological role of endogenous B7-H1 in the pathogenesis of herpetic stromal keratitis (HSK) caused by herpes simplex virus type 1 (HSV-1). Following HSV-1 infection of the cornea of mice, B7-H1 expression was up-regulated in the CD11b+ macrophage population in the draining lymph nodes (dLN) and in the inflamed cornea. In addition, HSV-1 infection significantly increased PD-1 expression on CD4+ T cells in the dLN and inflamed cornea. The administration of antagonistic B7-H1 monoclonal antibody resulted in the proliferation of HSV-specific CD4+ T cells that secreted interferon (INF)-γ, and inhibited the apoptosis of HSV-specific CD4+ T cells, which exaggerated HSK. These results strongly suggest that the B7-H1 may be involved in suppression of the development of HSK.

Original languageEnglish (US)
Pages (from-to)6259-6264
Number of pages6
JournalFEBS Letters
Volume579
Issue number27
DOIs
StatePublished - Nov 7 2005

Keywords

  • B7-H1
  • Herpes simplex virus type I
  • Herpetic stromal keratitis
  • PD-1

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Fingerprint Dive into the research topics of 'B7-H1 (CD274) inhibits the development of herpetic stromal keratitis (HSK)'. Together they form a unique fingerprint.

  • Cite this

    Jun, H., Seo, S. K., Jeong, H. Y., Seo, H. M., Zhu, G., Chen, L., & Choi, I. H. (2005). B7-H1 (CD274) inhibits the development of herpetic stromal keratitis (HSK). FEBS Letters, 579(27), 6259-6264. https://doi.org/10.1016/j.febslet.2005.09.098