B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion

Haidong Dong, Gefeng Zhu, Koji Tamada, Lieping Chen

Research output: Contribution to journalArticle

Abstract

The B7 family members B7-1 and B7-2 interact with CD28 and constitute an essential T-cell co-stimulatory pathway in the initiation of antigen-specific humoral and cell-mediated immune response. Here, we describe a third member of the B7 family, called B7-H1 that does not bind CD28, cytotoxic T- lymphocyte A4 or ICOS (inducible co-stimulator). Ligation of B7-H1 co- stimulated T-cell responses to polyclonal stimuli and allogeneic antigens, and preferentially stimulated the production of interleukin-10. Interleukin- 2, although produced in small amounts, was required for the effect of B7-H1 co-stimulation. Our studies thus define a previously unknown co-stimulatory molecule that may be involved in the negative regulation of cell-mediated immune responses.

Original languageEnglish (US)
Pages (from-to)1365-1369
Number of pages5
JournalNature Medicine
Volume5
Issue number12
DOIs
StatePublished - Dec 1999
Externally publishedYes

Fingerprint

T-cells
Cell proliferation
Interleukin-10
Inducible T-Cell Co-Stimulator Protein
Cell Proliferation
T-Lymphocytes
Antigens
Cytotoxic T-Lymphocytes
Interleukin-2
Ligation
Cells
Molecules

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion. / Dong, Haidong; Zhu, Gefeng; Tamada, Koji; Chen, Lieping.

In: Nature Medicine, Vol. 5, No. 12, 12.1999, p. 1365-1369.

Research output: Contribution to journalArticle

Dong, Haidong ; Zhu, Gefeng ; Tamada, Koji ; Chen, Lieping. / B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion. In: Nature Medicine. 1999 ; Vol. 5, No. 12. pp. 1365-1369.
@article{daabfa8f07e84e078dcdd0f968bfb127,
title = "B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion",
abstract = "The B7 family members B7-1 and B7-2 interact with CD28 and constitute an essential T-cell co-stimulatory pathway in the initiation of antigen-specific humoral and cell-mediated immune response. Here, we describe a third member of the B7 family, called B7-H1 that does not bind CD28, cytotoxic T- lymphocyte A4 or ICOS (inducible co-stimulator). Ligation of B7-H1 co- stimulated T-cell responses to polyclonal stimuli and allogeneic antigens, and preferentially stimulated the production of interleukin-10. Interleukin- 2, although produced in small amounts, was required for the effect of B7-H1 co-stimulation. Our studies thus define a previously unknown co-stimulatory molecule that may be involved in the negative regulation of cell-mediated immune responses.",
author = "Haidong Dong and Gefeng Zhu and Koji Tamada and Lieping Chen",
year = "1999",
month = "12",
doi = "10.1038/70932",
language = "English (US)",
volume = "5",
pages = "1365--1369",
journal = "Nature Medicine",
issn = "1078-8956",
publisher = "Nature Publishing Group",
number = "12",

}

TY - JOUR

T1 - B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion

AU - Dong, Haidong

AU - Zhu, Gefeng

AU - Tamada, Koji

AU - Chen, Lieping

PY - 1999/12

Y1 - 1999/12

N2 - The B7 family members B7-1 and B7-2 interact with CD28 and constitute an essential T-cell co-stimulatory pathway in the initiation of antigen-specific humoral and cell-mediated immune response. Here, we describe a third member of the B7 family, called B7-H1 that does not bind CD28, cytotoxic T- lymphocyte A4 or ICOS (inducible co-stimulator). Ligation of B7-H1 co- stimulated T-cell responses to polyclonal stimuli and allogeneic antigens, and preferentially stimulated the production of interleukin-10. Interleukin- 2, although produced in small amounts, was required for the effect of B7-H1 co-stimulation. Our studies thus define a previously unknown co-stimulatory molecule that may be involved in the negative regulation of cell-mediated immune responses.

AB - The B7 family members B7-1 and B7-2 interact with CD28 and constitute an essential T-cell co-stimulatory pathway in the initiation of antigen-specific humoral and cell-mediated immune response. Here, we describe a third member of the B7 family, called B7-H1 that does not bind CD28, cytotoxic T- lymphocyte A4 or ICOS (inducible co-stimulator). Ligation of B7-H1 co- stimulated T-cell responses to polyclonal stimuli and allogeneic antigens, and preferentially stimulated the production of interleukin-10. Interleukin- 2, although produced in small amounts, was required for the effect of B7-H1 co-stimulation. Our studies thus define a previously unknown co-stimulatory molecule that may be involved in the negative regulation of cell-mediated immune responses.

UR - http://www.scopus.com/inward/record.url?scp=0032736029&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032736029&partnerID=8YFLogxK

U2 - 10.1038/70932

DO - 10.1038/70932

M3 - Article

C2 - 10581077

AN - SCOPUS:0032736029

VL - 5

SP - 1365

EP - 1369

JO - Nature Medicine

JF - Nature Medicine

SN - 1078-8956

IS - 12

ER -