B7-DC induced by IL-13 works as a feedback regulator in the effector phase of allergic asthma

Koichiro Matsumoto; Satoru Fukuyama; Miyuki Eguchi-Tsuda; Takako Nakano; Takafumi Matsumoto; Mikiko Matsumura; Atsushi Moriwaki; Keiko Kan-o; Yoshihiro Wada; Hideo Yagita; Tahiro Shin; Drew M. Pardoll; Rirprajak Patcharee; Miyuki Azuma; Yoichi Nakanishi; Hiromasa Inoue

doi:10.1016/j.bbrc.2007.10.156

B7-DC induced by IL-13 works as a feedback regulator in the effector phase of allergic asthma

Koichiro Matsumoto, Satoru Fukuyama, Miyuki Eguchi-Tsuda, Takako Nakano, Takafumi Matsumoto, Mikiko Matsumura, Atsushi Moriwaki, Keiko Kan-o, Yoshihiro Wada, Hideo Yagita, Tahiro Shin, Drew M. Pardoll, Rirprajak Patcharee, Miyuki Azuma, Yoichi Nakanishi, Hiromasa Inoue

School of Medicine

Research output: Contribution to journal › Article › peer-review

42 Scopus citations

Abstract

B7-DC is a costimulatory molecule belonging to the B7 family. We previously found that treatment with anti-B7-DC mAb during the effector phase enhances asthma phenotypes in mice. We investigated the mechanisms of B7-DC induction and how B7-DC regulates asthma phenotypes. In allergen-challenged IFN-γ-deficient mice, anti-B7-DC mAb failed to enhance the asthma phenotypes although the induction of B7-DC on dendritic cells of the mice was comparable with that on dendritic cells of wild-type mice. B7-DC on dendritic cells was up-regulated by IL-13 in vitro. The induction of B7-DC on dendritic cells after allergen challenge was attenuated by blockade of IL-13 in vivo. The asthma phenotypes were enhanced in B7-DC-deficient mice, more than in wild-type mice. The enhancement was concurrent with the down-regulation of IFN-γ and up-regulation of IL-13. These results suggest that B7-DC induced by IL-13 works as a feedback regulator by up-regulating IFN-γ production during the effector phase of allergic asthma.

Original language	English (US)
Pages (from-to)	170-175
Number of pages	6
Journal	Biochemical and Biophysical Research Communications
Volume	365
Issue number	1
DOIs	https://doi.org/10.1016/j.bbrc.2007.10.156
State	Published - Jan 4 2008

Keywords

Allergy
Costimulatory molecule
Dendritic cell
IFN-γ
Mouse

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology
Cell Biology

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Matsumoto, K., Fukuyama, S., Eguchi-Tsuda, M., Nakano, T., Matsumoto, T., Matsumura, M., Moriwaki, A., Kan-o, K., Wada, Y., Yagita, H., Shin, T., Pardoll, D. M., Patcharee, R., Azuma, M., Nakanishi, Y., & Inoue, H. (2008). B7-DC induced by IL-13 works as a feedback regulator in the effector phase of allergic asthma. Biochemical and Biophysical Research Communications, 365(1), 170-175. https://doi.org/10.1016/j.bbrc.2007.10.156

Matsumoto, K, Fukuyama, S, Eguchi-Tsuda, M, Nakano, T, Matsumoto, T, Matsumura, M, Moriwaki, A, Kan-o, K, Wada, Y, Yagita, H, Shin, T, Pardoll, DM, Patcharee, R, Azuma, M, Nakanishi, Y & Inoue, H 2008, 'B7-DC induced by IL-13 works as a feedback regulator in the effector phase of allergic asthma', Biochemical and Biophysical Research Communications, vol. 365, no. 1, pp. 170-175. https://doi.org/10.1016/j.bbrc.2007.10.156

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title = "B7-DC induced by IL-13 works as a feedback regulator in the effector phase of allergic asthma",

abstract = "B7-DC is a costimulatory molecule belonging to the B7 family. We previously found that treatment with anti-B7-DC mAb during the effector phase enhances asthma phenotypes in mice. We investigated the mechanisms of B7-DC induction and how B7-DC regulates asthma phenotypes. In allergen-challenged IFN-γ-deficient mice, anti-B7-DC mAb failed to enhance the asthma phenotypes although the induction of B7-DC on dendritic cells of the mice was comparable with that on dendritic cells of wild-type mice. B7-DC on dendritic cells was up-regulated by IL-13 in vitro. The induction of B7-DC on dendritic cells after allergen challenge was attenuated by blockade of IL-13 in vivo. The asthma phenotypes were enhanced in B7-DC-deficient mice, more than in wild-type mice. The enhancement was concurrent with the down-regulation of IFN-γ and up-regulation of IL-13. These results suggest that B7-DC induced by IL-13 works as a feedback regulator by up-regulating IFN-γ production during the effector phase of allergic asthma.",

keywords = "Allergy, Costimulatory molecule, Dendritic cell, IFN-γ, Mouse",

author = "Koichiro Matsumoto and Satoru Fukuyama and Miyuki Eguchi-Tsuda and Takako Nakano and Takafumi Matsumoto and Mikiko Matsumura and Atsushi Moriwaki and Keiko Kan-o and Yoshihiro Wada and Hideo Yagita and Tahiro Shin and Pardoll, {Drew M.} and Rirprajak Patcharee and Miyuki Azuma and Yoichi Nakanishi and Hiromasa Inoue",

note = "Funding Information: This work was supported by a Grant-in-Aid for Scientific Research from the Ministry of Education, Science, and Culture of Japan. The authors thank Mses. Yuki Yoshioka, Tomoko Yoshimura, and Ayako Hashizume for technical assistance.",

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doi = "10.1016/j.bbrc.2007.10.156",

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T1 - B7-DC induced by IL-13 works as a feedback regulator in the effector phase of allergic asthma

AU - Matsumoto, Koichiro

AU - Fukuyama, Satoru

AU - Eguchi-Tsuda, Miyuki

AU - Nakano, Takako

AU - Matsumoto, Takafumi

AU - Matsumura, Mikiko

AU - Moriwaki, Atsushi

AU - Kan-o, Keiko

AU - Wada, Yoshihiro

AU - Yagita, Hideo

AU - Shin, Tahiro

AU - Pardoll, Drew M.

AU - Patcharee, Rirprajak

AU - Azuma, Miyuki

AU - Nakanishi, Yoichi

AU - Inoue, Hiromasa

N1 - Funding Information: This work was supported by a Grant-in-Aid for Scientific Research from the Ministry of Education, Science, and Culture of Japan. The authors thank Mses. Yuki Yoshioka, Tomoko Yoshimura, and Ayako Hashizume for technical assistance.

PY - 2008/1/4

Y1 - 2008/1/4

N2 - B7-DC is a costimulatory molecule belonging to the B7 family. We previously found that treatment with anti-B7-DC mAb during the effector phase enhances asthma phenotypes in mice. We investigated the mechanisms of B7-DC induction and how B7-DC regulates asthma phenotypes. In allergen-challenged IFN-γ-deficient mice, anti-B7-DC mAb failed to enhance the asthma phenotypes although the induction of B7-DC on dendritic cells of the mice was comparable with that on dendritic cells of wild-type mice. B7-DC on dendritic cells was up-regulated by IL-13 in vitro. The induction of B7-DC on dendritic cells after allergen challenge was attenuated by blockade of IL-13 in vivo. The asthma phenotypes were enhanced in B7-DC-deficient mice, more than in wild-type mice. The enhancement was concurrent with the down-regulation of IFN-γ and up-regulation of IL-13. These results suggest that B7-DC induced by IL-13 works as a feedback regulator by up-regulating IFN-γ production during the effector phase of allergic asthma.

AB - B7-DC is a costimulatory molecule belonging to the B7 family. We previously found that treatment with anti-B7-DC mAb during the effector phase enhances asthma phenotypes in mice. We investigated the mechanisms of B7-DC induction and how B7-DC regulates asthma phenotypes. In allergen-challenged IFN-γ-deficient mice, anti-B7-DC mAb failed to enhance the asthma phenotypes although the induction of B7-DC on dendritic cells of the mice was comparable with that on dendritic cells of wild-type mice. B7-DC on dendritic cells was up-regulated by IL-13 in vitro. The induction of B7-DC on dendritic cells after allergen challenge was attenuated by blockade of IL-13 in vivo. The asthma phenotypes were enhanced in B7-DC-deficient mice, more than in wild-type mice. The enhancement was concurrent with the down-regulation of IFN-γ and up-regulation of IL-13. These results suggest that B7-DC induced by IL-13 works as a feedback regulator by up-regulating IFN-γ production during the effector phase of allergic asthma.

KW - Allergy

KW - Costimulatory molecule

KW - Dendritic cell

KW - IFN-γ

KW - Mouse

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B7-DC induced by IL-13 works as a feedback regulator in the effector phase of allergic asthma

Abstract

Keywords

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