B-type natriuretic peptide as a marker for heart failure in patients with acute stroke

Matthew A. Koenig, H. Adrian Puttgen, Vivek Prabhakaran, Daniel Reich, Robert D. Stevens

Research output: Contribution to journalArticlepeer-review

25 Scopus citations


Objective: To determine whether serum N-terminal pro-B-type natriuretic peptide (N-BNP), a biomarker of myocardial wall stress, is specific to acute heart failure (HF) in patients hospitalized with stroke. Design: Case-control study. Setting: Tertiary hospital, Neurosciences Critical Care Unit and Stroke Unit. Patients: Consecutive patients with acute ischemic or hemorrhagic stroke who were evaluated for HF. Intervention: None. Measurements and results: Cases and controls were classified, respectively, as patients with or without HF, defined according to modified Framingham criteria. Seventy-two patients were evaluated, 39 with ischemic stroke, 22 with aneurysmal subarachnoid hemorrhage (SAH), and 11 with intracerebral hemorrhage (ICH). Thirty-four patients (47%) met criteria for HF, and 47 patients (65%) had systolic or diastolic left ventricular (LV) dysfunction on echocardiogram. Serum N-BNP was measured a median of 48 h following the onset of stroke and was increased (> 900 pg/ml) in 56 patients (78%), with higher levels in non-survivors (11898 ± 12741 vs 4073 ± 5691; p = 0.001). In a multiple regression model, N-BNP elevation was not independently associated with HF (OR 5.4, 95% CI 0.8-36.0, p = 0.084). At a cut-off of 900 pg/ml, the sensitivity of N-BNP for HF was 94%, specificity 37%, positive predictive value (PPV) 57%, and negative predictive value (NPV) 88%. For systolic or diastolic LV dysfunction, the sensitivity of N-BNP was 89%, specificity 44%, PPV 75%, and NPV 69%. Conclusions: These results demonstrate that N-BNP elevation is not specific to HF or LV dysfunction in patients with acute ischemic stroke, SAH, and ICH.

Original languageEnglish (US)
Pages (from-to)1587-1593
Number of pages7
JournalIntensive Care Medicine
Issue number9
StatePublished - Sep 2007


  • B-type natriuretic peptide
  • Heart failure
  • Intracerebral hemorrhage
  • Stroke
  • Subarachnoid hemorrhage

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine


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