B cells turn off virgin but not memory T cells

Ephraim J. Fuchs, Polly Matzinger

Research output: Contribution to journalArticlepeer-review

Abstract

There are three possible outcomes when a T cell recognizes a cell bearing a self or foreign antigen. (i) The T cell is not sufficiently signaled and is unaffected. (ii) The T cell is activated. (iii) The T cell is turned off. The differentiation state of the T cell is critical to the outcome. Although both virgin and memory T cells can be activated by antigens presented by "professional" antigen-presenting cells such as dendritic cells, they differ in their responses to B cells. Experienced T cells respond to antigen presented by B cells, whereas virgin T cells are rendered tolerant. These findings may relate to the phenomena of low- and high-zone tolerance, neonatal tolerance, and the beneficial effect of blood transfusions on allograft survival.

Original languageEnglish (US)
Pages (from-to)1156-1159
Number of pages4
JournalScience
Volume258
Issue number5085
DOIs
StatePublished - 1992

ASJC Scopus subject areas

  • General

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