B cells in cardiac transplants

From clinical questions to experimental models

William M. Baldwin, Marc K Halushka, Anna Valujskikh, Robert L. Fairchild

Research output: Contribution to journalArticle

Abstract

After many years of debate, there is now general agreement that B cells can participate in the immune response to cardiac transplants. Acute antibody-mediated rejection (AMR) is the best defined manifestation of B cell responses, but diagnostic and mechanistic questions still surround AMR. Many complement dependent mechanisms of antibody-mediated injury have been elucidated. C5 has become a therapeutic target that may not just truncate complement activation, but also may tip the balance away from inflammation by altering macrophage function. Additional complement independent effects have been identified. These may escape diagnosis and progress to chronic graft injury.The function of B cell infiltrates in cardiac transplants is even more enigmatic. Nodular endocardial infiltrates that contain B cells and plasma cells have been described in protocol biopsies of cardiac transplants for decades, but an understanding of their significance is still evolving based on more critical morphological and molecular evaluation of these infiltrates. A range of infiltrates containing B cells has also been described in the epicardial fat in transplants with advanced chronic rejection. B cells have been observed in endocardial and epicardial tertiary lymphoid nodules, but their impact on antigen presentation or antibody production remains to be determined. Experimental models in small and large animals suggest that B cells could be essential for the formation of lymphoid nodules through cytokine production. Similarly, the role of proinflammatory adipokines in the formation or function of epicardial lymphoid nodules has not been studied.These clinical observations provide critical questions to be addressed in experimental models.

Original languageEnglish (US)
Pages (from-to)122-130
Number of pages9
JournalSeminars in Immunology
Volume24
Issue number2
DOIs
StatePublished - Apr 2012

Fingerprint

B-Lymphocytes
Theoretical Models
Transplants
Antibodies
Adipokines
Complement Activation
Wounds and Injuries
Antigen Presentation
Plasma Cells
Antibody Formation
Fats
Macrophages
Cytokines
Inflammation
Biopsy

Keywords

  • Antibody mediated rejection
  • Complement activation
  • Endocardial lymphoid nodules
  • Perivascular adipose tissue
  • Tertiary lymphoid organogenesis

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

B cells in cardiac transplants : From clinical questions to experimental models. / Baldwin, William M.; Halushka, Marc K; Valujskikh, Anna; Fairchild, Robert L.

In: Seminars in Immunology, Vol. 24, No. 2, 04.2012, p. 122-130.

Research output: Contribution to journalArticle

Baldwin, William M. ; Halushka, Marc K ; Valujskikh, Anna ; Fairchild, Robert L. / B cells in cardiac transplants : From clinical questions to experimental models. In: Seminars in Immunology. 2012 ; Vol. 24, No. 2. pp. 122-130.
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