TY - JOUR
T1 - B-cell activation induced microRNA-21 is elevated in circulating B cells preceding the diagnosis of AIDS-related non-Hodgkin lymphomas
AU - Thapa, Dharma R.
AU - Bhatia, Kishor
AU - Bream, Jay H.
AU - D'Souza, Gypsyamber
AU - Rinaldo, Charles R.
AU - Wolinsky, Steven
AU - Detels, Roger
AU - Martínez-Maza, Otoniel
PY - 2012/6/1
Y1 - 2012/6/1
N2 - We show that microRNA-21 is significantly elevated in peripheral B cells of HIV-infected individuals who go on to develop AIDS-related non-Hodgkin lymphoma (n = 13, <3 years prior to diagnosis) when compared with HIV-negative (n = 18) or HIV-positive controls (n = 21) (P < 0.01). Moreover, miR-21 is overexpressed in activated B cells and can be induced by interleukin 4 alone, or with CD4 +0 or immunoglobulin M co-stimulation, and lipopolysaccharides, suggesting that miR-21 may help maintain B-cell hyperactivation, contributing to lymphomagenesis.
AB - We show that microRNA-21 is significantly elevated in peripheral B cells of HIV-infected individuals who go on to develop AIDS-related non-Hodgkin lymphoma (n = 13, <3 years prior to diagnosis) when compared with HIV-negative (n = 18) or HIV-positive controls (n = 21) (P < 0.01). Moreover, miR-21 is overexpressed in activated B cells and can be induced by interleukin 4 alone, or with CD4 +0 or immunoglobulin M co-stimulation, and lipopolysaccharides, suggesting that miR-21 may help maintain B-cell hyperactivation, contributing to lymphomagenesis.
UR - http://www.scopus.com/inward/record.url?scp=84861527530&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84861527530&partnerID=8YFLogxK
U2 - 10.1097/QAD.0b013e3283543e0e
DO - 10.1097/QAD.0b013e3283543e0e
M3 - Article
C2 - 22487708
AN - SCOPUS:84861527530
SN - 0269-9370
VL - 26
SP - 1177
EP - 1180
JO - AIDS
JF - AIDS
IS - 9
ER -