Azlocillin kinetics during extracorporeal haemodialysis and peritoneal dialysis

Andrew Whelton; Robert L. Stout; Fernando A. Delgado

doi:10.1093/jac/11.suppl_B.89

Azlocillin kinetics during extracorporeal haemodialysis and peritoneal dialysis

Andrew Whelton, Robert L. Stout, Fernando A. Delgado

School of Medicine

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

The kinetic disposition of azlocillin in patients with end stage renal failure was evaluated in six individuals maintained on chronic extracorporeal haemodialysis and in six individuals on peritoneal dialysis. In the absence of renal function the plasma half-life of azlocillin was extended from the normal value of approximately 60 min to 235 ± 30 min. During peritoneal dialysis the plasma half-life was reduced to 148 ± 15 min and during extracorporeal haemodialysis it was further reduced to 112 ± 11 min. Azlocillin was readily dialysed during haemodialysis but its removal rate during peritoneal dialysis was substantially less.

Original language	English (US)
Pages (from-to)	89-95
Number of pages	7
Journal	The Journal of antimicrobial chemotherapy
Volume	11
DOIs	https://doi.org/10.1093/jac/11.suppl_B.89
State	Published - 1983

ASJC Scopus subject areas

Pharmacology
Infectious Diseases
Pharmacology (medical)
Microbiology

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AU - Whelton, Andrew

AU - Stout, Robert L.

AU - Delgado, Fernando A.

PY - 1983

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N2 - The kinetic disposition of azlocillin in patients with end stage renal failure was evaluated in six individuals maintained on chronic extracorporeal haemodialysis and in six individuals on peritoneal dialysis. In the absence of renal function the plasma half-life of azlocillin was extended from the normal value of approximately 60 min to 235 ± 30 min. During peritoneal dialysis the plasma half-life was reduced to 148 ± 15 min and during extracorporeal haemodialysis it was further reduced to 112 ± 11 min. Azlocillin was readily dialysed during haemodialysis but its removal rate during peritoneal dialysis was substantially less.

AB - The kinetic disposition of azlocillin in patients with end stage renal failure was evaluated in six individuals maintained on chronic extracorporeal haemodialysis and in six individuals on peritoneal dialysis. In the absence of renal function the plasma half-life of azlocillin was extended from the normal value of approximately 60 min to 235 ± 30 min. During peritoneal dialysis the plasma half-life was reduced to 148 ± 15 min and during extracorporeal haemodialysis it was further reduced to 112 ± 11 min. Azlocillin was readily dialysed during haemodialysis but its removal rate during peritoneal dialysis was substantially less.

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JO - The Journal of antimicrobial chemotherapy

JF - The Journal of antimicrobial chemotherapy

ER -

Azlocillin kinetics during extracorporeal haemodialysis and peritoneal dialysis

Abstract

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