Azlocillin kinetics during extracorporeal haemodialysis and peritoneal dialysis

Andrew Whelton, Robert L. Stout, Fernando A. Delgado

Research output: Contribution to journalArticle

Abstract

The kinetic disposition of azlocillin in patients with end stage renal failure was evaluated in six individuals maintained on chronic extracorporeal haemodialysis and in six individuals on peritoneal dialysis. In the absence of renal function the plasma half-life of azlocillin was extended from the normal value of approximately 60 min to 235 ± 30 min. During peritoneal dialysis the plasma half-life was reduced to 148 ± 15 min and during extracorporeal haemodialysis it was further reduced to 112 ± 11 min. Azlocillin was readily dialysed during haemodialysis but its removal rate during peritoneal dialysis was substantially less.

Original languageEnglish (US)
Pages (from-to)89-95
Number of pages7
JournalThe Journal of antimicrobial chemotherapy
Volume11
DOIs
Publication statusPublished - 1983

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ASJC Scopus subject areas

  • Pharmacology
  • Infectious Diseases
  • Pharmacology (medical)
  • Microbiology

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