Azathioprine and acute pancreatitis: Studies with an isolated perfused canine pancreas

Patrick J. Broe, John L Cameron

Research output: Contribution to journalArticle

Abstract

Recent controlled clinical trials have documented the development of acute pancreatitis in 5% of patients receiving azathioprine for Crohn's disease, by far the highest incidence of drug-induced pancreatitis recorded to date. In an effort to evaluate the effects of azathioprine on the pancreas, the isolated ex vivo perfused canine pancreas model was used. No significant changes in gross appearance, weight, or serum amylase occurred in azathioprine-treated glands compared to controls. Azathioprine administration, however, resulted in a significant increase in secretory volume (two fold) and bicarbonate output (two fold), and a profound depression of trypsin output compared to controls. These preliminary studies demonstrate that azathioprine has marked effect on pancreatic function in this model.

Original languageEnglish (US)
Pages (from-to)159-163
Number of pages5
JournalJournal of Surgical Research
Volume34
Issue number2
DOIs
StatePublished - 1983

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Azathioprine
Pancreatitis
Canidae
Pancreas
Controlled Clinical Trials
Amylases
Bicarbonates
Crohn Disease
Trypsin
Weights and Measures
Incidence
Serum
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Surgery

Cite this

Azathioprine and acute pancreatitis : Studies with an isolated perfused canine pancreas. / Broe, Patrick J.; Cameron, John L.

In: Journal of Surgical Research, Vol. 34, No. 2, 1983, p. 159-163.

Research output: Contribution to journalArticle

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