Axonal Injury in Young Pediatric Head Trauma: A Comparison Study of β-amyloid Precursor Protein (β-APP) Immunohistochemical Staining in Traumatic and Nontraumatic Deaths

Michael W. Johnson, Lisa Stoll, Ana Rubio, Juan Troncoso, Olga Pletnikova, David R. Fowler, Ling Li

Research output: Contribution to journalArticlepeer-review

Abstract

We tested the independent utility of β-amyloid precursor protein (β-APP) immunohistochemical staining as evidence of brain trauma in the deaths of young children. Blinded reviewers retrospectively reviewed immunostained brain tissues from homicidal deaths, age-matched control cases without evidence of trauma, as well as cases of sudden infant death syndrome (SIDS). The reviewers correctly identified five of the seven cases with documented inflicted head trauma. However, one of seven age-matched control cases and one of 10 SIDS/sudden unexplained death in infancy (SUDI) cases demonstrated staining patterns similar to those seen in cases of inflicted trauma. We discuss these cases and the circumstances surrounding them with the intent to explain the difficulties associated with immunohistological interpretation of axonal injury. Although the utility of β-APP is quite powerful if not confounded by global hypoxic-ischemic injury, ultimately, β-APP studies should be only one piece of information in the determination of cause and manner of death.

Original languageEnglish (US)
Pages (from-to)1198-1205
Number of pages8
JournalJournal of Forensic Sciences
Volume56
Issue number5
DOIs
StatePublished - Sep 2011

Keywords

  • Amyloid precursor protein
  • Autopsy
  • Axonal injury
  • Forensic science
  • Pediatric
  • Traumatic brain injury

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Genetics

Fingerprint

Dive into the research topics of 'Axonal Injury in Young Pediatric Head Trauma: A Comparison Study of β-amyloid Precursor Protein (β-APP) Immunohistochemical Staining in Traumatic and Nontraumatic Deaths'. Together they form a unique fingerprint.

Cite this