Axonal degeneration affects muscle density in older men and women

Fulvio Lauretani, Stefania Bandinelli, Benedetta Bartali, Angelo Di Iorio, Vittoria Giacomini, Anna Maria Corsi, Jack M. Guralnik, Luigi Ferrucci

Research output: Contribution to journalArticlepeer-review

Abstract

Using data from InCHIANTI, a prospective population-based survey of older persons, we examined the relationship of peroneal nerve conduction velocity (NCV, a measure of nerve myelination) and compound muscle action potential (CMAP, a measure of axonal degeneration) with calf muscle mass and density, two complementary measures of sarcopenia. NCV and CMAP were assessed by surface electroneurography of the right peroneal nerve conducted in 1162 participants, 515 men and 647 women, age 21-96 years, free of major neurological diseases. Cross-sectional muscle area and calf muscle density were measured using peripheral quantitative computerized tomography (pQCT). Both nerve and muscle parameters declined with age although in most cases the decline was not linear. In both sexes, CMAP, but not NCV, was independently and significantly associated with calf muscle density. These findings suggest that intrinsic changes in the muscle tissue are partially caused by a reduction in the number of motor axons.

Original languageEnglish (US)
Pages (from-to)1145-1154
Number of pages10
JournalNeurobiology of Aging
Volume27
Issue number8
DOIs
StatePublished - Aug 2006
Externally publishedYes

Keywords

  • Axonal degeneration
  • Muscle density
  • Peroneal CMAP
  • Sarcopenia
  • Surface ENG

ASJC Scopus subject areas

  • Clinical Neurology
  • Biological Psychiatry
  • Developmental Neuroscience
  • Neurology
  • Psychology(all)

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