Awake animal SPECT: Overview and initial results

A. G. Weisenberger; B. Kross; S. Majewski; J. McKisson; V. Popov; J. Proffitt; A. Stolin; J. S. Baba; J. S. Goddard; S. J. Lee; M. F. Smith; B. Tsui; M. Pomper

doi:10.1109/NSSMIC.2008.4774513

Awake animal SPECT: Overview and initial results

A. G. Weisenberger, B. Kross, S. Majewski, J. McKisson, V. Popov, J. Proffitt, A. Stolin, J. S. Baba, J. S. Goddard, S. J. Lee, M. F. Smith, B. Tsui, M. Pomper

School of Medicine

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

A SPECT / X-ray CT system configured at Johns Hopkins University to image the biodistribution of radiopharmaceuticals in unrestrained, un-anesthetized mice has been constructed and tested on awake mice. The system was built by Thomas Jefferson National Accelerator Facility and Oak Ridge National Laboratory. SPECT imaging is accomplished using two gamma cameras, 10 cm × 20 cm in size based on a 2 × 4 array of Hamamatsu H8500 flat panel position sensitive photomultiplier tubes. A real-time optical tracking system utilizing three infrared cameras provides time stamped pose data of an awake mouse head during a SPECT scan. The six degrees of freedom (three translational and three rotational) pose data are used for motion correction during 3-D tomographic list-mode iterative image reconstruction. SPECT reconstruction of awake, unrestrained mice with motion compensation for head movement has been accomplished.

Original language	English (US)
Title of host publication	2008 IEEE Nuclear Science Symposium Conference Record, NSS/MIC 2008
Pages	5588-5591
Number of pages	4
DOIs	https://doi.org/10.1109/NSSMIC.2008.4774513
State	Published - 2008
Event	2008 IEEE Nuclear Science Symposium Conference Record, NSS/MIC 2008 - Dresden, Germany Duration: Oct 19 2008 → Oct 25 2008

Publication series

Name	IEEE Nuclear Science Symposium Conference Record
ISSN (Print)	1095-7863

Other

Other	2008 IEEE Nuclear Science Symposium Conference Record, NSS/MIC 2008
Country/Territory	Germany
City	Dresden
Period	10/19/08 → 10/25/08

ASJC Scopus subject areas

Radiation
Nuclear and High Energy Physics
Radiology Nuclear Medicine and imaging

Access to Document

10.1109/NSSMIC.2008.4774513

Cite this

Weisenberger, A. G., Kross, B., Majewski, S., McKisson, J., Popov, V., Proffitt, J., Stolin, A., Baba, J. S., Goddard, J. S., Lee, S. J., Smith, M. F., Tsui, B., & Pomper, M. (2008). Awake animal SPECT: Overview and initial results. In 2008 IEEE Nuclear Science Symposium Conference Record, NSS/MIC 2008 (pp. 5588-5591). [4774513] (IEEE Nuclear Science Symposium Conference Record). https://doi.org/10.1109/NSSMIC.2008.4774513

Awake animal SPECT : Overview and initial results. / Weisenberger, A. G.; Kross, B.; Majewski, S.; McKisson, J.; Popov, V.; Proffitt, J.; Stolin, A.; Baba, J. S.; Goddard, J. S.; Lee, S. J.; Smith, M. F.; Tsui, B.; Pomper, M.

2008 IEEE Nuclear Science Symposium Conference Record, NSS/MIC 2008. 2008. p. 5588-5591 4774513 (IEEE Nuclear Science Symposium Conference Record).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Weisenberger, AG, Kross, B, Majewski, S, McKisson, J, Popov, V, Proffitt, J, Stolin, A, Baba, JS, Goddard, JS, Lee, SJ, Smith, MF, Tsui, B & Pomper, M 2008, Awake animal SPECT: Overview and initial results. in 2008 IEEE Nuclear Science Symposium Conference Record, NSS/MIC 2008., 4774513, IEEE Nuclear Science Symposium Conference Record, pp. 5588-5591, 2008 IEEE Nuclear Science Symposium Conference Record, NSS/MIC 2008, Dresden, Germany, 10/19/08. https://doi.org/10.1109/NSSMIC.2008.4774513

Weisenberger, A. G. ; Kross, B. ; Majewski, S. ; McKisson, J. ; Popov, V. ; Proffitt, J. ; Stolin, A. ; Baba, J. S. ; Goddard, J. S. ; Lee, S. J. ; Smith, M. F. ; Tsui, B. ; Pomper, M. / Awake animal SPECT : Overview and initial results. 2008 IEEE Nuclear Science Symposium Conference Record, NSS/MIC 2008. 2008. pp. 5588-5591 (IEEE Nuclear Science Symposium Conference Record).

@inproceedings{f50510085bbb4d4593cc52f6ea54a4c2,

title = "Awake animal SPECT: Overview and initial results",

abstract = "A SPECT / X-ray CT system configured at Johns Hopkins University to image the biodistribution of radiopharmaceuticals in unrestrained, un-anesthetized mice has been constructed and tested on awake mice. The system was built by Thomas Jefferson National Accelerator Facility and Oak Ridge National Laboratory. SPECT imaging is accomplished using two gamma cameras, 10 cm × 20 cm in size based on a 2 × 4 array of Hamamatsu H8500 flat panel position sensitive photomultiplier tubes. A real-time optical tracking system utilizing three infrared cameras provides time stamped pose data of an awake mouse head during a SPECT scan. The six degrees of freedom (three translational and three rotational) pose data are used for motion correction during 3-D tomographic list-mode iterative image reconstruction. SPECT reconstruction of awake, unrestrained mice with motion compensation for head movement has been accomplished.",

author = "Weisenberger, {A. G.} and B. Kross and S. Majewski and J. McKisson and V. Popov and J. Proffitt and A. Stolin and Baba, {J. S.} and Goddard, {J. S.} and Lee, {S. J.} and Smith, {M. F.} and B. Tsui and M. Pomper",

year = "2008",

doi = "10.1109/NSSMIC.2008.4774513",

language = "English (US)",

isbn = "9781424427154",

series = "IEEE Nuclear Science Symposium Conference Record",

pages = "5588--5591",

booktitle = "2008 IEEE Nuclear Science Symposium Conference Record, NSS/MIC 2008",

}

TY - GEN

T1 - Awake animal SPECT

T2 - 2008 IEEE Nuclear Science Symposium Conference Record, NSS/MIC 2008

AU - Weisenberger, A. G.

AU - Kross, B.

AU - Majewski, S.

AU - McKisson, J.

AU - Popov, V.

AU - Proffitt, J.

AU - Stolin, A.

AU - Baba, J. S.

AU - Goddard, J. S.

AU - Lee, S. J.

AU - Smith, M. F.

AU - Tsui, B.

AU - Pomper, M.

PY - 2008

Y1 - 2008

N2 - A SPECT / X-ray CT system configured at Johns Hopkins University to image the biodistribution of radiopharmaceuticals in unrestrained, un-anesthetized mice has been constructed and tested on awake mice. The system was built by Thomas Jefferson National Accelerator Facility and Oak Ridge National Laboratory. SPECT imaging is accomplished using two gamma cameras, 10 cm × 20 cm in size based on a 2 × 4 array of Hamamatsu H8500 flat panel position sensitive photomultiplier tubes. A real-time optical tracking system utilizing three infrared cameras provides time stamped pose data of an awake mouse head during a SPECT scan. The six degrees of freedom (three translational and three rotational) pose data are used for motion correction during 3-D tomographic list-mode iterative image reconstruction. SPECT reconstruction of awake, unrestrained mice with motion compensation for head movement has been accomplished.

AB - A SPECT / X-ray CT system configured at Johns Hopkins University to image the biodistribution of radiopharmaceuticals in unrestrained, un-anesthetized mice has been constructed and tested on awake mice. The system was built by Thomas Jefferson National Accelerator Facility and Oak Ridge National Laboratory. SPECT imaging is accomplished using two gamma cameras, 10 cm × 20 cm in size based on a 2 × 4 array of Hamamatsu H8500 flat panel position sensitive photomultiplier tubes. A real-time optical tracking system utilizing three infrared cameras provides time stamped pose data of an awake mouse head during a SPECT scan. The six degrees of freedom (three translational and three rotational) pose data are used for motion correction during 3-D tomographic list-mode iterative image reconstruction. SPECT reconstruction of awake, unrestrained mice with motion compensation for head movement has been accomplished.

UR - http://www.scopus.com/inward/record.url?scp=67649234814&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=67649234814&partnerID=8YFLogxK

U2 - 10.1109/NSSMIC.2008.4774513

DO - 10.1109/NSSMIC.2008.4774513

M3 - Conference contribution

AN - SCOPUS:67649234814

SN - 9781424427154

T3 - IEEE Nuclear Science Symposium Conference Record

SP - 5588

EP - 5591

BT - 2008 IEEE Nuclear Science Symposium Conference Record, NSS/MIC 2008

Y2 - 19 October 2008 through 25 October 2008

ER -

Awake animal SPECT: Overview and initial results

Abstract

Publication series

Other

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this