Avoiding a Sticky Situation: Bypassing the Mucus Barrier for Improved Local Drug Delivery

Hannah C. Zierden, Aditya Josyula, Rachel L. Shapiro, Henry T. Hsueh, Justin Hanes, Laura M. Ensign

Research output: Contribution to journalReview articlepeer-review

Abstract

The efficacy of drugs administered by traditional routes is limited by numerous biological barriers that preclude reaching the intended site of action. Further, full body systemic exposure leads to dose-limiting, off-target side effects. Topical formulations may provide more efficacious drug and nucleic acid delivery for diseases and conditions affecting mucosal tissues, but the mucus protecting our epithelial surfaces is a formidable barrier. Here, we describe recent advances in mucus-penetrating approaches for drug and nucleic acid delivery to the ocular surface, the female reproductive tract, the gastrointestinal tract, and the airways.

Original languageEnglish (US)
JournalTrends in Molecular Medicine
DOIs
StateAccepted/In press - 2021

Keywords

  • drug delivery
  • mucoadhesive
  • mucoinert
  • mucus
  • mucus penetrating
  • nanomedicine

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology

Fingerprint Dive into the research topics of 'Avoiding a Sticky Situation: Bypassing the Mucus Barrier for Improved Local Drug Delivery'. Together they form a unique fingerprint.

Cite this