Abstract
The clinical and histopathologic variability of this common genetic disorder - a leading cause of renal failure - cannot be explained by inherited mutation. Instead, the disease evidently progresses by a second hit: somatic mutation superimposed on germline mutation. The source of the mutability appears to be DNA triple-helixing, as mediated by some odd genetic code, the longest polypyrimidine tract ever found in the human genome.
Original language | English (US) |
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Pages (from-to) | 81-102 |
Number of pages | 22 |
Journal | Hospital Practice |
Volume | 32 |
Issue number | 3 |
State | Published - Mar 15 1997 |
ASJC Scopus subject areas
- General Medicine