Autosomal dominant PKD gets an atomic map

Paul A. Welling

doi:10.1038/s41581-018-0066-7

Autosomal dominant PKD gets an atomic map

Research output: Contribution to journal › Comment/debate › peer-review

Abstract

The polycystin complex structure has been solved at near-atomic resolution. Its surprising architecture provides new insights into the transient receptor potential (TRP) family of cation channels and the pathogenesis of autosomal dominant polycystic kidney disease. This discovery should have a transformative impact on the development of treatment strategies to cure the disease.

Original language	English (US)
Pages (from-to)	725-726
Number of pages	2
Journal	Nature Reviews Nephrology
Volume	14
Issue number	12
DOIs	https://doi.org/10.1038/s41581-018-0066-7
State	Published - Dec 1 2018
Externally published	Yes

ASJC Scopus subject areas

Nephrology

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10.1038/s41581-018-0066-7

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abstract = "The polycystin complex structure has been solved at near-atomic resolution. Its surprising architecture provides new insights into the transient receptor potential (TRP) family of cation channels and the pathogenesis of autosomal dominant polycystic kidney disease. This discovery should have a transformative impact on the development of treatment strategies to cure the disease.",

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Autosomal dominant PKD gets an atomic map

Abstract

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