Autosomal dominant PKD gets an atomic map

Research output: Contribution to journalComment/debate

Abstract

The polycystin complex structure has been solved at near-atomic resolution. Its surprising architecture provides new insights into the transient receptor potential (TRP) family of cation channels and the pathogenesis of autosomal dominant polycystic kidney disease. This discovery should have a transformative impact on the development of treatment strategies to cure the disease.

Original languageEnglish (US)
Pages (from-to)725-726
Number of pages2
JournalNature Reviews Nephrology
Volume14
Issue number12
DOIs
StatePublished - Dec 1 2018
Externally publishedYes

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ASJC Scopus subject areas

  • Nephrology

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