Autosomal-dominant Fundus Flavimaculatus: Clinicopathologic Correlation

Pedro F. Lopez, Irene H. Maumenee, Zenaida de la Cruz, W. Richard Green

Research output: Contribution to journalArticlepeer-review

Abstract

The authors report the first clinicopathologic study of autosomaldominant fundus flavimaculatus with late-onset atrophic macular degeneration in a 62-year-old man. Results of histopathologic examination disclosed the retinal pigment epithelium (RPE) to be distended by a periodic acid-Schiff (PAS)-positive, acid mucopolysaccharide-negative material. Transmission electron microscopy showed marked accumulation of lipofuscin and melanolipofuscin granules within the RPE. The different modes of genetic transmission and ultrastructural heterogeneity suggest that fundus flavimaculatus is a clinical syndrome representing several genetically and mechanistically distinct disorders whose common endstage is a topographically similar accumulation of lipofuscin.

Original languageEnglish (US)
Pages (from-to)798-809
Number of pages12
JournalOphthalmology
Volume97
Issue number6
DOIs
StatePublished - Jan 1 1990

ASJC Scopus subject areas

  • Ophthalmology

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