Autosomal Dominant Congenital Cataract Associated With Chromosomal Translocation [t(3;4)(p26.2;p15) ]

Paul D. Reese, Cathy M. Tuck Muller, Irene H. Maumenee

Research output: Contribution to journalArticle

Abstract

We studied a family in which congenital cataracts were found in a father and son who had a reciprocal translocation between the short arms of chromosomes 3 and 4 [t(3;4)(p26.2;p15) ]. The father's parents and brother had normal chromosomes and no evidence of cataracts. While results of these studies do not prove a causal relationship, they do strongly suggest that the areas near the break points involved in the translocation (3p26.2 and 4p15) would be good sites for further investigations into the genetic basis of this type of cataract.

Original languageEnglish (US)
Pages (from-to)1382-1384
Number of pages3
JournalArchives of ophthalmology
Volume105
Issue number10
DOIs
StatePublished - Oct 1987

ASJC Scopus subject areas

  • Ophthalmology

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