Abstract
Maximum likelihood analysis for linkage between autosomal dominant aniridia and 12 biochemical and serological markers in a single large family showed a probable linkage between autosomal dominant aniridia and the enzyme acid phosphatase-1. The presence of an autosomal dominant aniridia gene linked to acid phosphatase-1 on chromosome arm 2p and the existence of an aniridia syndrome resulting from deletion of band 13 of the short arm of chromosome 11 establishes a chromosome basis for genetic heterogeneity of aniridia phenotypes.
Original language | English (US) |
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Pages (from-to) | 1580-1582 |
Number of pages | 3 |
Journal | Proceedings of the National Academy of Sciences of the United States of America |
Volume | 77 |
Issue number | 3 I |
DOIs | |
State | Published - 1980 |
Externally published | Yes |
ASJC Scopus subject areas
- General