Autosomal aneuploidy in mice: Generation and developmental consequences

J. D. Gearhart, M. T. Davisson, M. L. Oster-Granite

Research output: Contribution to journalArticlepeer-review

77 Scopus citations


Spontaneous aneuploidy in the mouse is uncommon, but specific mating schemes have been developed that produce aneuploid conceptuses at high frequencies. The most commonly reported aneuploid condition in the mouse is autosomal trisomy, in which there is an extra copy (in whole or in part) of a chromosome. In this review, we present several of the schemes used in producing trisomie, partially (tertiary) trisomie, and monosomic conceptuses and summarize the developmental consequences that are associated with each of the autosomal trisomies of the mouse.

Original languageEnglish (US)
Pages (from-to)789-801
Number of pages13
JournalBrain Research Bulletin
Issue number6
StatePublished - Jun 1986


  • Autosomal aneuploidy
  • Malformations
  • Mouse
  • Trisomy

ASJC Scopus subject areas

  • Neuroscience(all)


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