Autoradiography-based, three-dimensional calculation of dose rate for murine, human-tumor xenografts

Kenneth F. Koral, Cheuk S. Kwok, Farley E. Yang, Raya S. Brown, James C. Sisson, Richard L. Wahl

Research output: Contribution to journalArticle

Abstract

A Fast Fourier Transform method for calculating the three-dimensional dose rate distribution for murine, human-tumor xenografts is outlined. The required input includes evenly-spaced activity slices which span the tumor. Numerical values in these slices are determined by quantitative 125I autoradiography. For the absorbed dose-rate calculation, we assume the activity from both 131I- and 90Y-labeled radiopharmaceuticals would be distributed as is measured with the 125I label. Two example cases are presented: an ovarian-carcinoma xenograft with an IgG 2ak monoclonal antibody and a neuroblastoma xenograft with meta-iodobenzylguanidine (MIBG). Considering all the volume elements in a tumor, we show, by comparison of histograms and also relative standard deviations, that the measured 125I activity and the calculated 131I dose-rate distributions, are similarly non-uniform and that they are more non-uniform than the calculated 90Y dose-rate distribution. However, the maximum-to-minimum ratio, another measure of non-uniformity, decreases by roughly an order of magnitude from one distribution to the next in the order given above.

Original languageEnglish (US)
Pages (from-to)901-909
Number of pages9
JournalNuclear Medicine and Biology
Volume20
Issue number8
DOIs
StatePublished - Nov 1993

ASJC Scopus subject areas

  • Molecular Medicine
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

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