Autoradiographic characterization of 125I-neurotensin binding sites in human entorhinal cortex

Steven S. Wolf, Thomas M. Hyde, Terry W. Moody, Richard C. Saunders, Daniel R. Weinberger, Joel E. Kleinman

Research output: Contribution to journalArticlepeer-review

Abstract

The laminar and rostro-caudal distribution of 125I-neurotensin binding sites is described in human entorhinal cortex using quantitative autoradiography. Specific binding was most prominent over the cell clusters of layer II of the entorhinal cortex throughout its rostro-caudal extent. Dense binding was also observed in the adjacent presubiculum and cortical amygdaloid transition area, whereas minimal binding was detected in the hippocampus and dentate gyms. 125I-Neurotensin may serve as a selective probe for neurotensin receptor alterations and layer II-specific cytoarchitectural disturbances in the entorhinal cortex in neuropsychiatric diseases associated with abnormalities of the mesial temporal lobe.

Original languageEnglish (US)
Pages (from-to)353-358
Number of pages6
JournalBrain Research Bulletin
Volume35
Issue number4
DOIs
StatePublished - 1994
Externally publishedYes

Keywords

  • Entorhinal cortex
  • Human brain
  • Neurotensin
  • Receptor autoradiography

ASJC Scopus subject areas

  • Neuroscience(all)

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