Autoradiographic and functional development of gastric cholecystokinin receptors in the rat

Gary J. Schwartz, Timothy H. Moran, Paul R. McHugh

Research output: Contribution to journalArticlepeer-review


To determine the functional role for and the pharmacological specificity of developing gastrointestinal CCK receptors, in vitro pyloric contractility and autoradiographic CCK receptor binding were examined in pups aged 1-20 days. CCK contracted the gastroduodenal junction at all ages, while nonsulfated CCK-8 (d-CCK) was less potent. Autoradiographic studies revealed CCK binding localized to the gastroduodenal junction throughout development. MK-329, a specific type A CCK receptor antagonist, completely displaced 125I CCK-8 binding at all ages, while d-CCK displaced binding at ages at which d-CCK elicited gastroduodenal contractility. The results demonstrate a physiological role for and pharmacological specificity of neonatal gastroduodenal CCK receptors.

Original languageEnglish (US)
Pages (from-to)1199-1203
Number of pages5
Issue number6
StatePublished - 1990


  • Autoradiography
  • CCK
  • Gastric emptying
  • Ingestive behavior
  • Neonatal rat
  • Ontogeny
  • Pylorus
  • Receptors

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Endocrinology
  • Cellular and Molecular Neuroscience


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