Abstract
Atrophy of specific, regional, and generalized brain structures occurs as a result of the Alzheimer's disease (AD) process. Comparing AD patients with histopathological confirmation of the disease at autopsy to those without autopsy but who were clinically diagnosed using the same antemortem criteria will provide further evidence of the utility and accuracy of neuropsychological assessments at the time of diagnosis, as well as the efficacy of quantitative magnetic resonance imaging (qMRI) in demonstrating gross neuropathological changes associated with the disease. The Cache County Study of Aging provides a unique opportunity to determine how closely AD subjects with only the clinical diagnosis match similarly diagnosed AD subjects but with postmortem confirmation of the disease. qMRI volumes of various brain structures, as well as neuropsychological outcome measures from an expanded battery, were obtained in 31 autopsy-confirmed AD subjects and 45 clinically diagnosed AD subjects. Of the various qMRI variables examined, only total temporal lobe volume was different, where those with postmortem confirmation had reduced volume. No significant differences between the two groups were found with any of the neuropsychological outcome measures. These findings confirm the similarity in neuroimaging and neuropsychological assessment findings between those with just the clinical diagnosis of AD and those with an autopsy-confirmed diagnosis in the moderate-to-severe stage of the disease at the time of diagnosis.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 553-560 |
| Number of pages | 8 |
| Journal | Journal of Clinical and Experimental Neuropsychology |
| Volume | 29 |
| Issue number | 5 |
| DOIs | |
| State | Published - Jul 2007 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Clinical Neurology
- Neurology
- Psychology(all)
- Clinical Psychology
Cite this
Autopsy-confirmed Alzheimer's disease versus clinically diagnosed Alzheimer's disease in the Cache County Study on Memory and Aging : A comparison of quantitative MRI and neuropsychological findings. / Fearing, Michael A.; Bigler, Erin D.; Norton, Maria; Tschanz, Jo Ann; Hulette, Christine; Leslie, Carol; Welsh-Bohmer, Kathleen; Anthony, James; Brookmeyer, Ron; Burke, James; Carlson, Michelle C; Christopher, Eric; Corcoran, Chris; David, Marion; Gagliardi, Jane; Green, Robert; Hart, Andrea; Helms, Michael; Klein, Liz; Leslie, Carole; Morris, John; Munger, Ron; Onyike, Chiadikaobi U; Østbye, Truls; Petersen, Ron; Piercy, Kathy; Pieper, Carl; Plassman, Brenda; Rabins, Peter V; Raj, Pritham; Ray, Russell; Sanders, Linda; Steffens, David C.; Steinberg, Martin I; Toohill, Marty; Toone, Leslie; Townsend, Jeannette J.; Wengreen, Heidi; West, Nancy; Williams, Michael; Wyse, Bonita W.
In: Journal of Clinical and Experimental Neuropsychology, Vol. 29, No. 5, 07.2007, p. 553-560.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Autopsy-confirmed Alzheimer's disease versus clinically diagnosed Alzheimer's disease in the Cache County Study on Memory and Aging
T2 - A comparison of quantitative MRI and neuropsychological findings
AU - Fearing, Michael A.
AU - Bigler, Erin D.
AU - Norton, Maria
AU - Tschanz, Jo Ann
AU - Hulette, Christine
AU - Leslie, Carol
AU - Welsh-Bohmer, Kathleen
AU - Anthony, James
AU - Brookmeyer, Ron
AU - Burke, James
AU - Carlson, Michelle C
AU - Christopher, Eric
AU - Corcoran, Chris
AU - David, Marion
AU - Gagliardi, Jane
AU - Green, Robert
AU - Hart, Andrea
AU - Helms, Michael
AU - Klein, Liz
AU - Leslie, Carole
AU - Morris, John
AU - Munger, Ron
AU - Onyike, Chiadikaobi U
AU - Østbye, Truls
AU - Petersen, Ron
AU - Piercy, Kathy
AU - Pieper, Carl
AU - Plassman, Brenda
AU - Rabins, Peter V
AU - Raj, Pritham
AU - Ray, Russell
AU - Sanders, Linda
AU - Steffens, David C.
AU - Steinberg, Martin I
AU - Toohill, Marty
AU - Toone, Leslie
AU - Townsend, Jeannette J.
AU - Wengreen, Heidi
AU - West, Nancy
AU - Williams, Michael
AU - Wyse, Bonita W.
PY - 2007/7
Y1 - 2007/7
N2 - Atrophy of specific, regional, and generalized brain structures occurs as a result of the Alzheimer's disease (AD) process. Comparing AD patients with histopathological confirmation of the disease at autopsy to those without autopsy but who were clinically diagnosed using the same antemortem criteria will provide further evidence of the utility and accuracy of neuropsychological assessments at the time of diagnosis, as well as the efficacy of quantitative magnetic resonance imaging (qMRI) in demonstrating gross neuropathological changes associated with the disease. The Cache County Study of Aging provides a unique opportunity to determine how closely AD subjects with only the clinical diagnosis match similarly diagnosed AD subjects but with postmortem confirmation of the disease. qMRI volumes of various brain structures, as well as neuropsychological outcome measures from an expanded battery, were obtained in 31 autopsy-confirmed AD subjects and 45 clinically diagnosed AD subjects. Of the various qMRI variables examined, only total temporal lobe volume was different, where those with postmortem confirmation had reduced volume. No significant differences between the two groups were found with any of the neuropsychological outcome measures. These findings confirm the similarity in neuroimaging and neuropsychological assessment findings between those with just the clinical diagnosis of AD and those with an autopsy-confirmed diagnosis in the moderate-to-severe stage of the disease at the time of diagnosis.
AB - Atrophy of specific, regional, and generalized brain structures occurs as a result of the Alzheimer's disease (AD) process. Comparing AD patients with histopathological confirmation of the disease at autopsy to those without autopsy but who were clinically diagnosed using the same antemortem criteria will provide further evidence of the utility and accuracy of neuropsychological assessments at the time of diagnosis, as well as the efficacy of quantitative magnetic resonance imaging (qMRI) in demonstrating gross neuropathological changes associated with the disease. The Cache County Study of Aging provides a unique opportunity to determine how closely AD subjects with only the clinical diagnosis match similarly diagnosed AD subjects but with postmortem confirmation of the disease. qMRI volumes of various brain structures, as well as neuropsychological outcome measures from an expanded battery, were obtained in 31 autopsy-confirmed AD subjects and 45 clinically diagnosed AD subjects. Of the various qMRI variables examined, only total temporal lobe volume was different, where those with postmortem confirmation had reduced volume. No significant differences between the two groups were found with any of the neuropsychological outcome measures. These findings confirm the similarity in neuroimaging and neuropsychological assessment findings between those with just the clinical diagnosis of AD and those with an autopsy-confirmed diagnosis in the moderate-to-severe stage of the disease at the time of diagnosis.
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UR - http://www.scopus.com/inward/citedby.url?scp=34250349470&partnerID=8YFLogxK
U2 - 10.1080/13803390600826579
DO - 10.1080/13803390600826579
M3 - Article
C2 - 17564920
AN - SCOPUS:34250349470
VL - 29
SP - 553
EP - 560
JO - Journal of Clinical and Experimental Neuropsychology
JF - Journal of Clinical and Experimental Neuropsychology
SN - 1380-3395
IS - 5
ER -